Association between MCP-1 -2518A>G polymorphism and asthma susceptibility: a meta-analysis.

Wenli Chen,Hongmei Gao,Jiewei Cui,Jianpeng Zhang,Guoan Xiang

doi:10.1590/1414-431x20198549

Wenli Chen, Hongmei Gao + Show 3 more

Open Access

https://doi.org/10.1590/1414-431x20198549

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Abstract

The published data on the association between MCP-1 -2518A>G polymorphism and asthma susceptibility are inconclusive. Therefore, we performed a meta-analysis to estimate the impact of MCP-1 -2518A>G polymorphism on asthma susceptibility. PubMed, Web of Science, Wanfang, and China National Knowledge Infrastructure (CNKI) databases were used to identify eligible studies. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to calculate the strength of association. Sensitivity analysis was performed to evaluate the influence of individual studies on the estimates of overall effect, and funnel plots and Egger's test were used to assess publication bias. Eight publications with 1562 asthma patients and 1574 controls were finally identified. Overall, we found no significant association between MCP-1 -2518A>G polymorphism and asthma susceptibility in any of the genetic model comparisons. After stratified analysis by ethnicity, the results showed that a significant association with asthma risk was found in Caucasians in all the genetic models. However, a protective association was found in Africans under the dominant model. The present meta-analysis suggested that the MCP-1 -2518 A>G polymorphism is a risk factor for asthma in the Caucasian population, nevertheless it has a protective effect in the African population.

Highlights

Asthma is a chronic respiratory inflammation disease characterized by airway hyper-responsiveness, reversible airway obstruction, and airway wall remodeling to a variety of stimuli [1]
Inclusion and exclusion criteria The inclusion criteria of our study were as follows: 1) any human studies that estimated the prevalence of MCP-1 polymorphisms and asthma risk; 2) studies were published in English or Chinese; 3) genotype distributions or allele frequency of each study available for estimating an odds ratio (OR) with 95% confidence interval (CI); 4) sufficient results for data extraction, that is, number of subjects for each genotype in asthma and control groups
Meta-analysis results A summary of the meta-analysis findings concerning association between MCP-1 -2518 A4G polymorphism and asthma susceptibility is provided in Figure 2 and Supplementary Table S2

Summary

Introduction

Asthma is a chronic respiratory inflammation disease characterized by airway hyper-responsiveness, reversible airway obstruction, and airway wall remodeling to a variety of stimuli [1]. Elevated MCP-1 expression has been demonstrated in the bronchial epithelium of asthmatic patients [7], and comparison of the same asthmatic patients showed marked elevation of sputum MCP-1 levels preceding exacerbation of acute asthma attacks compared to the asymptomatic state [11]. These accumulated data support the idea that MCP-1 plays an important role in asthma pathogenesis and the MCP-1 gene may be a susceptibility gene of asthma

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