Abstract
Objective: This study aimed to identify the distribution of matrix metalloproteinase (MMP)-1 −1607 1G/2G alleles and genotypes in subjects withchronic periodontitis and healthy subjects in a sample of Indonesian population and assess the possible association of this polymorphism withsusceptibility to chronic periodontitis.Methods: Genomic DNA samples were obtained from 200 Indonesian males aged 33–78 years old, comprising 100 chronic periodontitis patientsand 100 healthy controls. DNA fragments were amplified by a polymerase chain reaction and analyzed by restriction fragment length polymorphism.Results were analyzed by Chi-square test.Results: The frequency of the 2G allele was high both in subjects with periodontitis (87%) and in controls (91%). Analysis of MMP-1 genotype(−1607 1G/2G) showed no significant difference between the chronic periodontitis and healthy groups (p>0.05).Conclusion: The result found no association between MMP-1 −1607 1G/2G polymorphism and susceptibility to chronic periodontitis in Indonesiansubjects.
Highlights
Periodontitis is an inflammatory disease of the supporting dental tissue that is initiated by specific microorganisms or groups of specific microorganisms, causing periodontal apparatus destruction by means of loss of clinical attachment (CAL) [1,2,3,4]
We have investigated the prevalence of periodontal diseases in Indonesia, finding that chronic periodontitis was the most common form of periodontal disease at 75.2%; a weak positive correlation was found between age and chronic periodontitis [5]
The presence of the 2G allele was not related to increased risk of chronic periodontitis (p=0.201, odds ratio (OR)=0.662, 95% confidence interval (95% CI)=0.350–1.250)
Summary
Periodontitis is an inflammatory disease of the supporting dental tissue that is initiated by specific microorganisms or groups of specific microorganisms, causing periodontal apparatus destruction by means of loss of clinical attachment (CAL) [1,2,3,4]. We have investigated the prevalence of periodontal diseases in Indonesia, finding that chronic periodontitis was the most common form of periodontal disease at 75.2%; a weak positive correlation was found between age and chronic periodontitis [5]. Taken together, these findings suggest that genetics might contribute to susceptibility to periodontal disease. Sample selection, race, and ethnic background may all contribute to the inconsistent findings across the previous studies. Further study is needed to examine the distribution of MMP-1 genotypes in other populations to confirm if it is a genetic marker of chronic periodontitis
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