Association between lztfl1 gene variation and risk infection of COVID-19 in holy Najaf province patients

Abstract

Coronavirus disease 19 (COVID-19), is acute aspiratory syndrome caused by coronavirus 2 (SARS-CoV-2). Factors such as age, health status (cardiovascular disease, diabetes) and gender are the most important risk factors in terms of their relationship to the host ability to infected with COVID-19. However, the genetic association evidence has been unclear yet in our population. This study, demonstrated genetic predisposition investigation to detect SNPs allele locus 3p21.31at of rs11385942 associations with COVID-19 infection. Statistical analysis and DNA sequences analysis were conducted to the study cases. The results showed male incidences is higher than female number (60 cases- 60% male) corresponding (40 cases40% female). COVID-19 impact significantly on C-reactive protein and the age group 55-65 appeared high level of CRP (130.5 ± 58.93). While, DNA sequence using Sanger sequencing method with further alignments analysis showed the association signal at locus 3p21.31 genes homozygous allele AA/AA frequent exist for the rs11385942 as risk allele in sever patients who have diabetes type 1 or 2 and received oxygen supplementation. However, no heterozygous alleles mutant was detected To conclude, that aged patients and male paralleled the severity of COVID-19.