Association Between Lymph Node Silicosis and Lung Silicosis in 4,384 German Uranium Miners With Lung Cancer

Abstract

ABSTRACT This study investigates the association between lymph node–only and lung silicosis in uranium miners with lung cancer and exposure to quartz dust. Tissue slides of 4,384 German uranium miners with lung cancer were retrieved from an autopsy archive and reviewed by 3 pathologists regarding silicosis in the lungs and lymph nodes. Cumulative exposure to quartz dust was assessed with a quantitative job-exposure matrix. The occurrence of silicosis by site was investigated with regression models for exposure to quartz dust. Miners with lung silicosis had highest cumulative quartz exposure, followed by lymph node–only silicosis and no silicosis. At a cumulative quartz exposure of 40 mg/m3 × years, the probability of lung silicosis was above 90% and the likelihood of lymph node–only silicosis and no silicosis do not differ anymore. The results support that lymph node silicosis can precede lung silicosis, at least in a proportion of subjects developing silicosis, and that lung silicosis strongly depends on the cumulative quartz dose.