Abstract
Abstract Introduction: Deterioration of lung function is the main cause of mortality in cystic fibrosis (CF), so it is essential to study different related factors. Objective: To assess the association of pulmonary function with thoracoabdominal mobility and postural alignment in individuals with CF. Method: A cross-sectional study was performed in individuals with CF (8-17 years). Pulmonary function was assessed by spirometry. Thoracoabdominal mobility and postural alignment were evaluated by photogrammetry using the Postural Assessment Software (PAS/Sapo). Pearson correlation coefficient analysis was performed, and p < 0.05 was considered significant. Results: The following spirometric variables showed a decrease compared to predicted values: FEV1, FEV1/FVC, PEF and FEF25-75%. Postural assessment showed alterations in head horizontal alignment (HHA; 2.71 ± 2.23o), acromion horizontal alignment (AHA; 1.33 ± 1.35o), anterior superior iliac spine (ASIS) horizontal alignment (ASISHA; 1.11 ± 0.89o), angle between acromia and ASIS (AAASIS; 0.89 ± 0.39o), scapula horizontal asymmetry - T3 (SHAT3; 16.95 ± 12.03%), and asymmetry of the projection of the center of gravity within the base of support in the frontal (11.45 ± 8.10%) and sagittal (48.98 ± 18.55%) planes. A strong positive correlation was found between pulmonary function and thoracoabdominal mobility in the variables anteroposterior mobility of the upper chest (APMUC) and FVC (r = 0.818, p = 0.024), APMUC and FEV1 (r = 0.874, p = 0.010), and APMUC and FEF25-75% (r = 0.797, p = 0.032). A strong negative correlation was detected between FEV1/FVC and AHA (r = -0.761, p = 0.047). Conclusion: Our study showed in CF a reduction in pulmonary function, strong positive correlation between APMUC and pulmonary function, high prevalence of kyphoscoliosis and strong negative correlation between AHA and pulmonary function.
Highlights
Deterioration of lung function is the main cause of mortality in cystic fibrosis (CF), so it is essential to study different related factors
Our study showed in CF a reduction in pulmonary function, strong positive correlation between anteroposterior mobility of the upper chest (APMUC) and pulmonary function, high prevalence of kyphoscoliosis and strong negative correlation between acromion horizontal alignment (AHA) and pulmonary function
42 individuals diagnosed with CF, in the study age group and cared for at HINSG, were initially selected, of whom the following were excluded for the noted reasons: two had autism; three did not attend the evaluations on the scheduled days; 26 did not agree to participate because they lived in other municipalities; and 3 did not agree to participate for other reasons
Summary
Deterioration of lung function is the main cause of mortality in cystic fibrosis (CF), so it is essential to study different related factors. The survival of individuals with CF has increased due to several factors including: better knowledge of the pathophysiology, early diagnosis, new drug development, treatment in specialized centers and follow-up by an interdisciplinary team [1], considered essential according to national [5] and international [6,7] guidelines, and the recommendation for respiratory physiotherapy at diagnosis and for life [5,6,7] Despite these advances, due to the progressive deterioration of the lung parenchyma in CF, most deaths still occur from respiratory failure, which can be triggered or aggravated by respiratory pump failure, which includes the respiratory muscles, rib cage and neuromuscular components, and studies on each of these aspects are important.
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