Association between Low-density lipoprotein cholesterol and occipital periventricular hyperintensities in a group of Chinese patients: an observational study

Dazhi Duan,Chun Cui,Jian Zheng,Tongsheng Shu,Lin Shen

doi:10.1186/s12944-017-0436-3

Dazhi Duan, Chun Cui + Show 3 more

Open Access

https://doi.org/10.1186/s12944-017-0436-3

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Abstract

BackgroundWhile occipital periventricular hyperintensities (OPVHs) are among the most common mild white matter hyperintensities, the clinical factors associated with OPVHs remain unclear. In this study, we investigated the role of clinical factors in development of pure OPVHs.MethodsThis study included 97 patients with OPVHs and 73 healthy controls. Univariate analysis of clinical factors in OPVH patients and controls was followed by binomial logistic regression analysis to identify clinical factors significantly associated with OPVHs.ResultUnivariate analysis indicated that age, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein-B (Apo-B) levels differed significantly between the OPVH patients and controls (p < 0.05). Age and gender were correlated with OPVH scores (p < 0.05), while LDL-C, triglycerides, Apo-B and TC were anti-correlated with OPVHs scores (p < 0.05). Multivariate analysis indicated that LDL-C is negatively correlated with OPVHs (p < 0.05), and age is positively correlated with OPVHs (p < 0.001).ConclusionIn summary, LDL-C was negatively and age was positively associated with OPVHs among Chinese patients in a hospital.

Highlights

While occipital periventricular hyperintensities (OPVHs) are among the most common mild white matter hyperintensities, the clinical factors associated with OPVHs remain unclear
In summary, low-density lipoprotein cholesterol (LDL-C) was negatively and age was positively associated with OPVHs among Chinese patients in a hospital
Spearman correlation analysis indicated that age (p < 0.001) and gender (p < 0.05) were correlated with OPVHs, while LDL-C (p < 0.001), TG (p < 0.05), Apo-B (p < 0.001) and total cholesterol (TC) (p < 0.05) were anti-correlated with OPVHs

Summary

Introduction

While occipital periventricular hyperintensities (OPVHs) are among the most common mild white matter hyperintensities, the clinical factors associated with OPVHs remain unclear. We investigated the role of clinical factors in development of pure OPVHs. White matter hyperintensities (WMHs), which reflect chronic vascular ischemic diseases, may only represent extreme cases of white matter injury [1]. Previous studies have investigated WMH progression and its clinical significance [2]. The optimal treatment regimen remains to be elucidated [3]. WMH can be categorized as periventricular hyperintensities (PVHs) or deep white matter hyperintensities (DWMHs) [4]. As the severity of the lesions increase, PVHs can extend into the deep white matter (DWM) and may subsequently develop into confluence DWMHs [5].

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