Abstract
Long non-coding RNAs (LncRNAs) play vital roles in the tumorigenesis of many cancers. Single nucleotide polymorphisms (SNPs) of the lncRNA also play vital roles in tumorigenesis. We explored lncRNA rs944289 and rs7990916 polymorphisms and analyzed the relationship between these lncRNA polymorphisms with the colorectal cancer (CRC) risk in a Chinese population. We recruited 1003 CRC patients from the Affiliated People’s Hospital of Jiangsu University and the Fujian Medical University Union Hospital from October 2014 to August 2017. Genomic DNA was extracted using a DNA Kit from lymphocytes of peripheral blood and the genotyping was performed with a SNPscan method. We found that the rs944289 TT homozygote was associated with the decreased CRC risk in the overall population. LncRNA rs944289 TT decreased the CRC risk in the subgroup of female, male, age ≥ 61, without alcohol intake, smoking and BMI ≥ 24 by logistic regression. The subgroup analysis revealed that lncRNA rs7990916 was not associated with CRC risk except for age < 61. Logistic regression analysis revealed that lncRNA rs944289 TT homozygote was associated with the increased risk of rectum cancer (TT vs. CC + CT: adjusted OR = 1.29, 95% CI 1.10–1.66, P = 0.041) or colon cancer. In summary, we proved that lncRNA rs944289 might be significantly related to the decreased CRC risk in the Chinese Han populations and lncRNA rs7990916 was not associated with the CRC risk except for patients of age < 61. In the future, studies with larger samples should be conducted to validate our results.
Highlights
Long non-coding RNAs (LncRNAs) play vital roles in the tumorigenesis of many cancers
Smoking, alcohol intake and body mass index (BMI) increased the risk of colorectal cancer (CRC), so we adjusted these factors by multiple logistic regression analyses
Our results revealed that there was no significant difference between Long noncoding RNAs (lncRNAs) rs7990916 polymorphism and the CRC risk in an overall comparison
Summary
Long non-coding RNAs (LncRNAs) play vital roles in the tumorigenesis of many cancers. Single nucleotide polymorphisms (SNPs) of the lncRNA play vital roles in tumorigenesis. We explored lncRNA rs944289 and rs7990916 polymorphisms and analyzed the relationship between these lncRNA polymorphisms with the colorectal cancer (CRC) risk in a Chinese population. We proved that lncRNA rs944289 might be significantly related to the decreased CRC risk in the Chinese Han populations and lncRNA rs7990916 was not associated with the CRC risk except for patients of age < 61. Xu et al found that lncRNA rs944289 have no effect on the risk of breast cancer (BC)[14] These data indicate SNPs in lncRNAs play important roles in tumorigenesis. LncRNA rs944289 and rs7990916 polymorphisms have a risk effect on some diseases, there are no studies concerning the relationship of these two variants with CRC risk. We explored lncRNA rs944289 and rs7990916 polymorphisms in CRC patients and analyzed the relationship between these lncRNA polymorphisms and CRC risk
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