Abstract
BackgroundHypertension is a major cardiovascular risk factor for cognitive impairment. Lipid accumulation product (LAP), an index that represents fat overaccumulation in the body, has been shown to be associated with cardiovascular disease. Nevertheless, the relationship between LAP and cognitive function in hypertensive patients with normal weight has been infrequently studied.ObjectiveThis study aimed to assess the relationship between LAP and cognitive function in hypertensive patients with normal weight.MethodsThis study included 5,542 Chinese hypertensive patients with normal weight. Cognitive function was evaluated using the Mini-Mental State Examination (MMSE). The relationship between LAP and MMSE scores was evaluated using multiple linear regression.ResultsThe mean age of the participants was 64.8 ± 9.3 years, and 2,700 were men (48.7%). The mean MMSE score was 24.5 ± 5.1 in men and 19.2 ± 6.5 in women. The mean LAP was 26.2 ± 25.5 in men and 42.5 ± 34 in women. Log10-LAP showed a significant positive association with MMSE score (men: β = 0.69, 95% CI 0.14–1.24, p = 0.015; women: β = 1.03, 95% CI 0.16–1.90, p = 0.020). When LAP was divided into 3 groups according to tertiles, participants in the third LAP tertile had higher MMSE scores for both men (p for trend = 0.04) and women (p for trend = 0.015).ConclusionLAP showed an independent positive association with MMSE in Chinese hypertensive patients with normal weight.
Highlights
According to the World Alzheimer Report 2015, ∼46.8 million people are living with dementia worldwide, and this number is predicted to exceed 131.5 million by 2050 [1]
Log10-Lipid accumulation product (LAP) showed a significant positive association with Mini-Mental State Examination (MMSE) score
When LAP was divided into 3 groups according to tertiles, participants in the third LAP tertile had higher MMSE scores for both men (p for trend = 0.04) and women (p for trend = 0.015)
Summary
According to the World Alzheimer Report 2015, ∼46.8 million people are living with dementia worldwide, and this number is predicted to exceed 131.5 million by 2050 [1]. Several cohort studies have suggested that high blood pressure in middle-aged individuals is linked to an increased risk of cognitive decline over time [3,4,5]. Obesity is considered a risk factor for dementia [6, 7]. The association between obesity and the risk of dementia is unclear. A recent meta-analysis reported a positive association between obesity in middle age and subsequent dementia, but a negative association was noted between these two parameters in old age [8]. Hypertension is a major cardiovascular risk factor for cognitive impairment. Lipid accumulation product (LAP), an index that represents fat overaccumulation in the body, has been shown to be associated with cardiovascular disease. The relationship between LAP and cognitive function in hypertensive patients with normal weight has been infrequently studied
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