Abstract
Association between leptin and leptin receptor gene polymorphisms and breast cancer risk in premenopausal and postmenopausal Mexican women
Highlights
Breast cancer (BC) is a heterogeneous and complex disease due to an interaction between environmental factors and genetic susceptibility
Purpose: This study aims to evaluate the association between leptin (-2548 G>A) and leptin receptor (p.K109R, p.Q223R, p.K656N) polymorphisms with breast cancer (BC) risk in premenopausal and postmenopausal Mexican women
Four polymorphisms were genotyped by polymerase chain reaction (PCR), High Resolution Melting, and DNA direct sequencing. χ2, logistic regression analysis was performed with SPSS and XLSTAT software
Summary
Breast cancer (BC) is a heterogeneous and complex disease due to an interaction between environmental factors and genetic susceptibility. A cytokine of the adipocytes encoded by the leptin (LEP) gene, interacts with the leptin receptor (LEPR), which is present in breast and other tissues [4]. LEP 2548G>A polymorphism seems to influence leptin mRNA expression in breast cancer cell lines affecting signaling capacity and receptor functionality, increasing the LEPR-LEP binding capacity [7,8]. This induces a cascade of events in the tumor microenvironment, causing the proliferation, angiogenesis, and invasion of the cell [9, 10]. QR and RR genotypes of the LEPR p.Q223R polymorphism have been associated with modest risk for BC in nonobese premenopausal women [11], whereas QR and QR+QQ genotypes of the LEPR p.Q223R polymorphism with BC in overweight postmenopausal women [12]
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