Association between knee extensor muscle strength and incident radiographic and symptomatic knee osteoarthritis in middle-aged or older adults with medial meniscal pathology: the most study

Abstract

s / Osteoarthritis and Cartilage 22 (2014) S7–S56 S43 We then performed sensitivity analyses restricting to those with KL grade < 2 at baseline. Results: For the medial JSN analysis, 2424 people were included with a meanage of 59.5 (9.0) years,meanBMI of 27.7 (4.6) kg/m2, 39%weremale, 81% were white. For the lateral JSN analysis, 3905 people were included with ameanageof62.1 (9.1) years,meanBMIof 28.5 (4.8) kg/m2, 43%were male, 81%werewhite. Sensitivity analyses restricting to thosewith KL< 2 at baseline were similar to those reported in tables 1 and 2. Conclusions: This study identifies that PP and perhaps SBP are associated with incident radiographic medial TF OA. Because PP is known to be elevated when arteries are stiff, additional studies studying a possible relationship between elevated pulse pressure, arterial stiffness, and medial TF OA are warranted. Further study of underlying mechanisms to explainwhy PP and SBP may be associated with medial but not lateral TF OA is warranted. 66 ASSOCIATION BETWEEN KNEE EXTENSOR MUSCLE STRENGTH AND INCIDENT RADIOGRAPHIC AND SYMPTOMATIC KNEE OSTEOARTHRITIS IN MIDDLE-AGED OR OLDER ADULTS WITH MEDIAL MENISCAL PATHOLOGY: THE MOST STUDY J.B. Thorlund y, D.T. Felson z, N.A. Segal x, T. Neogi z, M.C. Nevitt k, C.E. Lewis{, J. Niu z, A. Guermazi z, F.W. Roemer z#, M. Englund zyy. yUniv. of Southern Denmark, Odense M, Denmark; zBoston Univ., Boston, MA, USA; xUniv. of Iowa, Iowa City, IA, USA; kUniv. of California at San Francisco, San Francisco, CA, USA; {Univ. of Alabama at Birmingham, Birmingham, AL, USA; Klinikum Augsburg, Augsburg, Germany; yy Lund Univ., Lund, Sweden Purpose: Patients with knee osteoarthritis (OA) often have impaired knee extensor strength. There is also evidence that high knee extensor strength may postpone or prevent knee OA development in the general population. Hypothetically, the importance of knee extensor strength maybe evenmore pronounced in subjects at high risk of kneeOA.Hence, our aim was to determine the association between knee extensor strength and incident radiographic whole knee OA (ROA) and incident symptomatic radiographic whole knee OA (SxOA) in participants with meniscal pathology. We hypothesized that higher baseline knee extensor strength would be associated with a lower risk for incident ROA and incident SxOA among those with pre-existing meniscal pathology. Table 2 Incident symptomatic whole knee osteoarthritis in persons with medial meniscal pathol