Abstract
BackgroundThe intercellular adhesion molecule‐1 (ICAM‐1)/leukocyte function associated antigen‐1 (LFA‐1) adhesion system regulates leukocyte interactions, migration, and adhesion, and appears to play an important role in atherosclerosis and thrombosis. Therefore, single nucleotide polymorphisms (SNPs) of the ICAM‐1 gene may strongly influence the expression and biological activity of ICAM‐1 and play a potentially important role in the pathogenesis of ischemic stroke. In the current meta‐analysis, we investigated the relationship between the ICAM‐1 gene K469E SNP and the risk of ischemic stroke.MethodsTwo investigators independently searched PubMed, Web of Science, Google Scholar, WANFANG, China National Knowledge Infrastructure (CNKI) and J‐STAGE for studies published from January 2000 to February 2019 without language restriction. The association of K469E polymorphism and ischemic stroke in three genetic models (allelic, recessive, and dominant) were evaluated using Pooled odds ratios (ORs) with 95% confidence intervals (CIs).ResultsOur study included 20 studies from four continents and four different countries, including 3,137 cases and 15,382 controls. Meta‐analysis results did not show a significant association between K469E polymorphism of ICAM‐1 gene and ischemic stroke when assuming allelic model (OR: 1.12; 95% CI: 0.8 to 1.55; p = 0.51; I 2 = 93%) or recessive model (OR: 1.28; 95% CI: 0.89 to 1.84; p = 0.18; I 2 = 82%) or dominant model (OR: 1.20; 95% CI: 0.92 to 1.56; p = 0.17; I 2 = 85%). However, in all three genetic models, subgroup analysis revealed that the K469E polymorphism of the ICAM‐1 gene is associated with ischemic stroke in the Caucasian population.ConclusionK469E polymorphism of ICAM‐1 gene might be a risk factor for ischemic stroke in Caucasians, which suggested that K469E polymorphism might help in early identification of those at risk and help in primary prevention of ischemic stroke.
Highlights
The intercellular adhesion molecule‐1 (ICAM‐1)/leukocyte function associated antigen‐1 (LFA‐1) adhesion system regulates leukocyte interactions, mi‐ gration, and adhesion, and appears to play an important role in atherosclerosis and thrombosis
We included studies that were conducted on human sub‐ jects and the studies were searched without any limitations on language. In this meta‐analysis, all included studies met the following criteria: (a) case–control studies focused on the association between K469E polymorphism and is‐ chemic stroke susceptibility; (b) patients with ischemic stroke were diagnosed with neuroimaging confirmed by neurologist; and (c) there were sufficient data of the geno‐ types in the case–control groups to evaluate the odds ratios (ORs) and 95% confidence intervals (CIs)
Meta‐analysis results did not show a significant association between K469E polymorphism of ICAM‐1 gene and ischemic stroke when assuming allelic model (OR: 1.12; 95% CI: 0.8 to 1.55; p = 0.51; I2 = 93%) or recessive model (OR: 1.28; 95% CI: 0.89 to 1.84; p = 0.18; I2 = 82%) or dominant model (OR: 1.20; 95% CI: 0.92 to 1.56; p = 0.17; I2 = 85%)
Summary
Stroke is the second leading cause of death after ischemic heart disease and the leading cause of long‐term disability. The ICAM‐1/LFA‐1 adhesion system regulates leu‐ kocyte interactions, migration and adhesion and appears to play an important role in early atherosclerosis (Wee et al, 2009). The SNP of ICAM‐1 gene may strongly influence the expression and biological activity of ICAM‐1, and has a potentially important role in the pathogenesis of ischemic stroke. Multitudes of studies have been conducted to determine the association between K469E SNPs and ischemic stroke, but their results are inconsistent. A meta‐analyses of 12 studies have been conducted previously to elucidate the association between K469E polymorphism and the risk of ischemic stroke (Zhang et al, 2014). We conducted extensive review of the literature and conducted a meta‐analysis to assess the rela‐ tionship between the ICAM‐1 gene K469E polymorphism and susceptibility to ischemic stroke
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
