Abstract
PurposeColorectal neoplasm and ischemic heart disease (IHD) share common risk factors. However, clinical guidance about screening or surveillance of colorectal neoplasm in patients with IHD has not been made. The aim of this study was to investigate the relationship between IHD and the development of colorectal neoplasm.MethodsA systematic literature review was conducted using the core databases (MEDLINE through PubMed, EMBASE, and the Cochrane Library). The data about the association between IHD and the development of colorectal neoplasm were extracted and analyzed using odds ratio (OR). A random effect model was applied. The methodological quality of the enrolled studies was assessed by the Newcastle–Ottawa Scale. Publication bias was evaluated through the funnel plot with trim and fill method, Egger’s test, and the rank correlation test.ResultsA total of 3069 patients from 4 non-randomized studies were enrolled. IHD was associated with colorectal neoplasm (OR 1.869, 95 % CI 1.375–2.542, p < 0.001). Sensitivity analyses showed consistent results. Publication bias was not detected.ConclusionPatients with IHD is associated with colorectal neoplasm, which warrants screening or surveillance of colorectal neoplasm in this group of patients.
Highlights
Colorectal cancer and ischemic heart disease (IHD) are one of the leading causes of death worldwide
Selection criteria We included randomized or non-randomized studies that met the following criteria: 1. the study was designed to evaluate the prevalence of IHD in patients with colorectal neoplasm or vice versa, or 2. the study was designed to evaluate the association between IHD and colorectal neoplasm
Characteristics of studies Within the 4 studies (Crosara Teixeira et al 2014; DerSimonian and Laird 1986; Sterne and Egger 2001; Stone et al 2014), we identified a total of 3069 patients
Summary
Colorectal cancer and ischemic heart disease (IHD) are one of the leading causes of death worldwide. Colorectal cancer is the third most common cause of mortality due to cancer (Begg and Mazumdar 1994). IHD is responsible for about one-third of mortality over age 35 (Borenstein et al 2009). There have been reports about common risk factors shared by these two conditions, such as diabetes, smoking, dyslipidemia, or sedentary life style (including alcohol and smoking) (Botteri et al 2008; Cai et al 2015; Chan et al 2006; Chan et al 2007; Crosara Teixeira et al 2014).
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