Abstract
The present study was conducted to determine the association between parathyroid hormone 1-34 administration and ectopic calcification in rats with glucocorticoid induced osteoporosis. A total of 18 rats were used in the current study. Osteoporosis was induced in all rats via dexamethasone administration, then rats were randomly distributed into Control and Forteo groups and were sacrificed 4 weeks after initiation of drug administration. Hemi-mandibles were decalcified followed by routine histological analysis. Among the Forteo group rats, three rats displayed the presence of ectopic calcification. True pulp stone, intra-pulpal calcified structure with entrapped cells and intra periodontal bone-like calcified structure with entrapped cells were observed while no ectopic calcification was noticed in the control group.
Highlights
Ectopic calcification is pathologic deposition of minerals within soft tissues as dental pulp or periodontal ligaments (PDL)1,2
Despite the fact that Parathyroid hormone (PTH) 1–34 can successfully lower blood calcium level, and prevent vascular calcification34, in the current work, PTH 1–34 was associated with ectopic calcifications within the pulp and PDL, while none was observed in the control group specimens
Guimaraes et al elucidated that PTH 1–34 can regulate odontoblast like cells via protein kinase A- and protein kinase C-dependent pathways, with increases in odontoblast-like cells proliferation upon short PTH exposure and increases in their apoptosis upon longer exposure36
Summary
Ectopic calcification is pathologic deposition of minerals within soft tissues as dental pulp or periodontal ligaments (PDL). Pulpal ectopic calcification may manifest as generalized, linear calcification, or as circumscribed calcification ( known as pulp stones or denticles). Pulp stones can be seen free within the pulp tissues, partially associated with dentin wall or completely embedded in dentin. They may manifest as false concentric calcification or true pulp stones. The etiology of pulp calcification may be idiopathic, it may be associated with pulp injury or degeneration, orthodontic or physical forces or chemical stimuli. Its incidence tends to increase with age
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