Association between interleukin 6, 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population

Abstract

ObjectiveTo investigate the relationship between the interleukin 6 (IL6) gene single nucleotide polymorphisms (SNP)-572C/G (rs1800796), interleukin 10 (IL10)-592A/C(rs1800872) and risk of type 2 diabetes mellitus (T2DM) in a Chinese population. Materials and methodsWe conducted a community-based, case-control study with a total of 568 subjects (284 patients and 284 controls) enrolled. Two polymorphisms of IL6 (rs1800796) and IL10 (rs1800872) were examined using TaqMan nuclease technology. ResultsThe study recruited 284 patients with T2DM and 284 healthy controls. Subjects carrying the -572 ‘G’ allele had an increased risk of T2DM (odds ratio [OR] 1.46, 95% confidence interval [CI] 1.077, 1.862), as did those subjects carrying the -572 GG+CG genotype (OR 1.431, 95% CI 1.026, 1.997). For rs1800872, subjects carrying the -592 AA+AC genotype had a significantly increased risk of T2DM (OR 3.040, 95% CI 1.336, 6.917) too. In double combination, IL-6-572 GG and IL-10-592 AA increased the risk of T2DM up to 21.250 (3.280–137.667) times. ConclusionsOur results suggest that IL6 and IL10 genes increased the risk of T2DM. Individuals having a haplotype combination of GG and AA for IL-6 and IL-10 gene polymorphisms will have higher susceptibility and be at greater risk of developing T2DM.