Abstract
0382 Previous research in youth has noted an inverse relationship between aerobic power (VO2max) and insulin sensitivity, but it is not known how weight status influences this relationship. PURPOSE: To determine the effect of obesity on the relationship between aerobic power and insulin sensitivity. METHODS: Fasting blood samples were collected on 84 normal weight (BMI = 19.3+/−2.2) and 74 overweight (BMI≥ 85 %tile; NHANES 2002), 11 to 18 years old youth. The age and sex distributions were similar between groups. Plasma was analyzed for insulin (RIA) and glucose (colorimetric procedures). Insulin sensitivity was estimated using the QUICKI and HOMA methods. Age, sex, body mass index, and aerobic power were obtained as described by McMurray et al. (Eur J Appl Physiol. 2000). RESULTS: Compared to normal weight, overweight youth had higher HOMA (p < 0.001), lower QUICKI (p < 0.001), and lower VO2max (p < 0.001). In overweight youth VO2max was significantly correlated with HOMA (r = −0.302; p = 0.01) and QUICKI (r = 0.311; p = 0.01). None of these associations were significant in normal weight youth (p > 0.48). CONCLUSION: It appears that differences in fatness explain the different associations between VO2max and insulin sensitivity in youth. The results suggest that in overweight, but not normal weight youth, higher aerobic power is associated with increased insulin sensitivity. Supported by NINR#RO1-1837.
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