Abstract
Introduction:Benign prostatic hyperplasia (BPH) is the most common benign disease in older men characterized by stromal and epithelial cell hyperplasia. Insulin is an independent risk factor and a promoter of BPH. Insulin resistance may change the risk of BPH through several biological pathways.Aim and objective: Aim of our studyis to estimate the insulin resistance and prostatic specific antigen level in the patients suffering from benign prostatic hyperplasia and compare them with the control.Materials and Methods : Hospital based cross sectional case control study.40 BPH-patients (aged above 50 years), clinically diagnosed and supported by serum PSA and USG findings were selected as case.Results:Insulin resistance was found to be elevated in the patients suffering from BPH. HOMA-IR score of cases was compared with the controls and found to be significantly elevated.A significant increase in fasting glucose level and PSA level were found in cases compared to controls. Conclusion: The insulin resistance was found to be significantly higher in patients.Further study regarding the relationships between metabolic syndrome and benign prostate diseases, including its underlying mechanisms is necessary.International Journal of Human and Health Sciences Vol. 05 No. 02 April’21 Page: 240-245
Highlights
Benign prostatic hyperplasia (BPH) is the most common benign disease in older men characterized by stromal and epithelial cell hyperplasia
Benign prostatic hyperplasia (BPH) is characterized by the non-malignant overgrowth of prostatic tissue surrounding the urethra, constricting the urethral opening and giving rise to associated lower tract symptoms (LUTS) like urgency, frequency, nocturia, incomplete bladder emptying, and weak urine stream serious complications can be occur in men with BPH, including acute retentiveness (AUR), insufficiency and failure, tract infection, and bladder stones[4]
Aim of our study is to estimate the insulin resistance and prostatic specific antigen level within the patients affected by benign prostatic hyperplasia and compare them with the control
Summary
Benign prostatic hyperplasia (BPH) is the most common benign disease in older men characterized by stromal and epithelial cell hyperplasia. Case history,race/ethnicity, hypertension, type II diabetes , obesity, body height, cigarette smoking, low HDL-C, and high insulin levels were reported to be risk factors for the event of BPH.6-9The main disorders in metabolic syndrome, which was characterized with insulin resistance and hyperinsulinemia, are localized in muscle, fat tissues, and the liver[10]. The compensatory hyperinsulinemia prevents development of fasting hyperglycemia in insulin-resistant individuals, the increased level of circulating insulin directly and/or indirectly affects different molecular signaling and may promote prostatic growth.
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