Abstract
Background: A substantial proportion of Influenza morbidity and mortality is due to secondary pneumococcal infection. Although the synergistic interaction between influenza and pneumococcal disease is well studied, the interplay between influenza and nasopharyngeal carriage of Streptococcus pneumoniae remains unclear. We test the hypothesis that influenza infection increases susceptibility of pneumococcal carriage in a high HIV prevalence setting.
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