Abstract
Results 185 children with JIA (median age 7.2 years(IQR 3.6, 11.7), 65% female) were included. Median CHAQ score at presentation was 0.75(IQR 0.13, 1.38). There was a trend towards higher disability with increased number of copies of the rare allele of rs2104286 (Table 1) (OR 8.00 (0.93, 68.79), p = 0.06). An association was also seen between increased disability and homozygosity for the rare allele of rs11594656 (OR 3.37 (0.89–12.75), p = 0.07). There was no association with rs41295061. Conclusion Children homozygous for the rare allele (rs2104286) a SNP associated with JIA susceptibility, showed a trend towards increased disability. Interestingly, a second SNP in the IL2RA region not previously associated with JIA susceptibility also showed a similar trend. Validation of these results in larger cohorts is required. from 15th Paediatric Rheumatology European Society (PreS) Congress London, UK. 14–17 September 2008
Highlights
Childhood Arthritis Prospective Study (CAPS) was designed to study clinical and genetic predictors of juvenile idiopathic arthritis (JIA) outcome
15th Paediatric Rheumatology European Society (PreS) Congress Wietse Kuis, Patricia Woo, Angelo Ravelli, Hermann Girschick, Michaël Hofer, Johannes Roth, Rotraud K Saurenmann, Alberto Martini, Pavla Dolezova, Janjaap van der Net, Pierre Quartier, Lucy Wedderburn and Jan Scott Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
This study investigates the association between SNPs located within the IL2RA region and disease severity at first presentation to rheumatology
Summary
Disease severity at first presentation to paediatric rheumatology: results from the Childhood Arthritis Prospective Study (CAPS). Address: 1University of Manchester, Manchester, UK, 2Institute of Child Health, London, UK, 3Royal Hospital for Sick Children, Glasgow, UK, 4Royal Liverpool Children's Hospital, Liverpool, UK, 5University of Newcastle, Newcastle, UK and 6Royal Manchester Children's Hospital, Manchester, UK. Published: 15 September 2008 Pediatric Rheumatology 2008, 6(Suppl 1):P14 doi:10.1186/1546-0096-6-S1-P14. 15th Paediatric Rheumatology European Society (PreS) Congress Wietse Kuis, Patricia Woo, Angelo Ravelli, Hermann Girschick, Michaël Hofer, Johannes Roth, Rotraud K Saurenmann, Alberto Martini, Pavla Dolezova, Janjaap van der Net, Pierre Quartier, Lucy Wedderburn and Jan Scott Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
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