Abstract
ABSTRACTInterleukin-18 (IL-18) is a pleiotropic cytokine involved in the regulation of innate and acquired immune response and plays a key role in autoimmune and inflammatory diseases. Recently it was shown that IL-18 expression is regulated by the IL18 gene promoter The aim of the present study was to examine the association between five polymorphisms in the IL18 gene (rs 1946518, rs187238, rs360722, rs360721, rs5744292) and the release of IL-18 from stimulated peripheral blood mononuclear cells. The study was performed on peripheral blood mononuclear cells from 62 healthy subjects; the cells were stimulated with PHA, LPS, or anti-CD3/CD28 antibodies. There were no statistically significant associations between the studied polymorphisms and IL-18 concentration, whereas some genotypes were associated with increased release of this cytokine. These results suggest that the studied polymorphisms of the IL18 gene are not significantly associated with IL-18 production in stimulated peripheral blood mononuclear cells.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
