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Abstract
BackgroundA number of observational studies have been conducted to investigate the association of IL-10 gene polymorphisms with tuberculosis (TB) susceptibility. However, the results of different studies were inconsistent. The aim of this study was to investigate the relationship between IL-10 -1082G/A, -819T/C, and -592A/C polymorphisms and TB risk by meta-analysis.MethodsA literature search was conducted among six English databases (PubMed, Embase, Web of Science, Science Direct, SpringerLink and EBSCO) and two Chinese databases (Wanfang and Chinese National Knowledge Infrastructure databases) to identify studies involving association between IL-10 −1082G/A, −819T/C, and −592A/C polymorphisms and TB susceptibility before May. 2013. Statistical analysis was performed using Revman 5.0 and Stata 12.0.ResultsA total of 31 studies with 6,559 cases and 7,768 controls were included in this meta-analysis. The results showed that three polymorphisms (-1082G/A, -819T/C, and -592A/C) in the IL-10 gene were not associated with the risk of TB in general population. In the subgroup analysis by ethnicity, IL-10 -1082G/A polymorphism was associated with TB risk in Europeans (AA+AG vs. GG: OR = 0.57, 95% CI = 0. 0.37–0.89, P = 0.01) and Americans (AA+AG vs. GG: OR = 0.39, 95% CI = 0.27–0.57, P<0.01), and IL-10 -819T/C (C allele vs. T allele: OR = 0.83, 95% CI = 0.72–0.96, P = 0.01) and -592A/C (CC+AC vs. AA: OR = 0.65, 95% CI = 0.49–0.85, P = 0.002) polymorphisms were significantly associated with TB risk in Asians.ConclusionThis meta-analysis provides strong evidence that IL-10-1082G/A polymorphism was associated with TB risk in Europeans and Americans, and IL-10 -819T/C and -592A/C polymorphisms could be risk factors for TB in Asians. Additional well designed large studies were required for the validation of our results.
Highlights
Tuberculosis (TB) is a chronic infectious disease that occurs worldwide, leading to 1.6 million deaths annually worldwide [1]
Key words used in the research included ‘‘interleukin’’, ‘‘interleukin-10’’, ‘‘cytokine’’, ‘‘tuberculosis’’, ‘‘Mycobacterium tuberculosis’’, ‘‘single nucleotide polymorphism’’, ‘‘variant’’, ‘‘genotype’’, ‘‘mutation’’
Among the 31 eligible studies, 17 of them were of Asians [16,18,19,26,28,30,31,32,34,36,39,41,42,43,44,46], 6 studies were of Europeans [17,21,25,27,35,37], 5 studies were of Africans [20,22,29,33,38], and 3 studies were of Americans [23,24,40]
Summary
Tuberculosis (TB) is a chronic infectious disease that occurs worldwide, leading to 1.6 million deaths annually worldwide [1]. The exact reasons as to why only some of the individuals exposed to M. tuberculosis develop uncontrolled disease and others have an effective immune response to limit the spread of the pathogen remains unknown. The genetic influence on TB infection was established by several studies of monozygotic and dizygotic twins, linkage and candidate gene analysis, indicating that genetics may play a role in the susceptibility to TB infection [3,4,5]. The ability of IL-10 to down-regulate immune responses and the fact that IL10 can be detected in tuberculosis patients have led researchers to investigate whether IL-10 plays a role in susceptibility to tuberculosis [10,11]. A number of observational studies have been conducted to investigate the association of IL-10 gene polymorphisms with tuberculosis (TB) susceptibility. The aim of this study was to investigate the relationship between IL-10 -1082G/A, -819T/C, and -592A/C polymorphisms and TB risk by meta-analysis
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