Abstract
BackgroundSeveral studies looking into the association between insulin-like growth factor-1 (IGF-1) gene polymorphisms and osteoporosis predisposition have been conducted among Chinese population with conflicting outcomes. The present systematic review and meta-analysis was performed to appraise and synthesize the existing evidence, so as to provide a more precise and reliable association between polymorphisms in IGF-1 gene and osteoporosis.MethodsFive electronic databases including PubMed, EMBASE, ISI Web of Science, CNKI and Wanfang were systematically searched for potential studies. Summary odds ratio (OR) and corresponding 95% confidence interval (95% CI) were calculated to evaluate the association. The best-matching genetic model of inheritance was determined using a genetic-model free approach.ResultsSix case-control studies comprising 2068 osteoporosis patients and 2071 healthy controls were obtained for the meta-analysis. Dominant model was confirmed to be the best-matching genetic model (TT + TC versus CC). The overall data suggested that rs35767 polymorphism was significantly associated with osteoporosis vulnerability (OR 1.21, 95% CI 1.07, 1.37; P = 0.002). When stratifying the participants and performing subgroup-analysis according to source of patients, the result suggested that rs35767 was significantly correlated to osteoporosis in post-menopausal women subgroup (OR 1.29, 95% CI 1.08, 1.54; P = 0.005), but the correlation was not established in the subgroup of both gender (OR 1.14, 95% CI 0.96, 1.35; P = 0.12).ConclusionTaken together, the findings of our current study suggested a significant association between rs35767 polymorphism and risk of osteoporosis in Chinese post-menopausal women.
Highlights
Several studies looking into the association between insulin-like growth factor-1 (IGF-1) gene polymorphisms and osteoporosis predisposition have been conducted among Chinese population with conflicting outcomes
Inclusion and exclusion criteria Studies included in our meta-analysis had to satisfy all of the following criteria: (1) osteoporosis diagnosed on the basis of radiological examination; (2) published studies aimed to assess the correlation between IGF-1 gene polymorphisms and osteoporosis; (3) case-control designed studies; (4) sufficient data provided for the calculation of the crude odds ratios (ORs) and 95% confidence intervals
A total of 228 records were yielded comprising 85 from PubMed, 22 from EMBASE, 112 from ISI Web of Science, 5 from China National Knowledge Infrastructure (CNKI) and 4 from Wanfang, and no additional records were gained by the manual retrieval
Summary
Several studies looking into the association between insulin-like growth factor-1 (IGF-1) gene polymorphisms and osteoporosis predisposition have been conducted among Chinese population with conflicting outcomes. The present systematic review and meta-analysis was performed to appraise and synthesize the existing evidence, so as to provide a more precise and reliable association between polymorphisms in IGF-1 gene and osteoporosis. Similar to other complex chronic disease in the elderly, the precise etiopathogenesis underlying osteoporosis is multifactorial. Risk factors such as genetics, age, physical activity, diet, the use of glucocorticoids and so forth have to be taken into account [3]. A series of candidate genes like vitamin D receptor [7, 8], estrogen receptors [9, 10], Gao et al BMC Musculoskeletal Disorders (2018) 19:141 osteoprotegerin [11, 12], have been widely reported to be associated with osteoporosis
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