Abstract

Hypokalemia is found in peritoneal dialysis (PD) patients. The problem may be severe and promote mortality. Several factors may trigger the hypokalemia in PD patients, such as preexisting malnutrition and the low protein and potassium food intake. To verify the prevalence of hypokalemia and its association with mortality, nutrition status, clinical, laboratory and electrocardiographic variables in PD patients. Serum K+ levels were evaluated retrospectively in PD patients. Hypokalemia was defined when the average of serum K+ was < 3.5 mEq/L in six consecutive measurements. Other available biochemical tests were also evaluated. Subjective Global Assessment (SGA) and body mass index (BMI) were used to assess the nutrition status. A questionnaire was applied to identify the most common symptoms and signals associated to hypokalemia. An electrocardiogram was performed. Demographic data, dialysis characteristics and survival rate were collected. Hypokalemia was present in 15 out of 110 patients (13.6%). The survival rate was lower in the hypokalemic group (p = 0.002). Hypokalemia was only associated with serum levels of albumin and urea, and with the SGA results. Low levels of serum potassium were associated to lower survival in PD patients and it seems to be related to malnutrition.

Highlights

  • Hypokalemia is found in peritoneal dialysis (PD) patients

  • The total study population consisted of all active patients in a PD program, including those undergoing continuous ambulatory peritoneal dialysis (CAPD) and in automated peritoneal dialysis (APD)

  • Our study showed that hypokalemia occurred in approximately 14% of PD patients and that it was associated with a high mortality

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Summary

Introduction

Hypokalemia is found in peritoneal dialysis (PD) patients. The problem may be severe and promote mortality. Several factors may trigger the hypokalemia in PD patients, such as preexisting malnutrition and the low protein and potassium food intake. Methods: Serum K+ levels were evaluated retrospectively in PD patients. Hypokalemia was only associated with serum levels of albumin and urea, and with the SGA results. Conclusion: Low levels of serum potassium were associated to lower survival in PD patients and it seems to be related to malnutrition. Patients may have low intake of protein and foods rich in potassium, preexisting malnutrition, and comorbid conditions. The intake of dietary potassium can vary significantly between individuals and on different days for the same person.[8] The combination of high loss and low reserve or intake may contribute to the severe hypokalemia in PD patients

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