Abstract
BackgroundTo explore the association between atrial fibrillation (AF) and serum uric acid (SUA) in a general population in rural China.MethodsFrom January 2013 to August 2013, we performed a cross-sectional study involving 11,956 permanent residents ≥ 35 years old in the rural Liaoning province of China. All participants completed a questionnaire, had a physical examination, and underwent an electrocardiogram (ECG) and echocardiogram. AF was diagnosed from ECG findings and/or a history of physician-confirmed AF. Blood samples were drawn for laboratory analyses and hyperuricemia was defined as an SUA level > 7.0 mg/dL in men and > 5.7 mg/dL in women, based on the NHANES-III laboratory definition. Logistic regression analyses were performed to estimate the crude and independent associations between hyperuricemia and the prevalence of AF.ResultsA total of 139 participants were diagnosed with AF, of which, 72 were self-reported, 45 were ECG-diagnosed, and 22 were both. There was a higher prevalence of AF in participants with hyperuricemia than those with normal SUA levels (2.4 vs. 1.0 %; P < 0.001). The odds ratios (OR) and 95 % confidence intervals (CI) were 2.37 (1.61–3.49) when compared to participants with normal SUA. After adjustment for other cardiovascular and AF risk factors, the independent association remained (OR = 1.94, 95 % CI: 1.26–3.00). Similar associations were observed between SUA as a continuous variable and AF prevalence (adjusted OR = 1.20, 95 % CI: 1.06–1.36). The independent associations were significant in men (Ps < 0.05) but not in women (Ps > 0.05), although the interaction logistic regression analyses presented these differences as not being statistically significant (Ps > 0.05).ConclusionsSUA is positively associated with the prevalence of AF in rural China.
Highlights
To explore the association between atrial fibrillation (AF) and serum uric acid (SUA) in a general population in rural China
The prevalence of AF was significantly higher in participants with hyperuricemia than those with normal SUA (P < 0.001)
Note: data are expressed as mean ± standard deviation or n (%) AF atrial fibrillation, BMI body mass index, DBP diastolic blood pressure, ECG-LVH left ventricular hypertrophy detected by electrocardiography, Fasting blood glucose (FBG) fasting blood glucose, LVEF left ventricular ejection fraction, MI myocardial infarction, SBP systolic blood pressure, SUA serum uric acid, TC total cholesterol, TG triglycerides, Waist circumference (WC) waist circumference normal SUA levels at every age
Summary
Study population A representative sample of men and women ≥ 35 years of age from rural areas of Liaoning Province were recruited between January 2013 and August 2013 using a multistage, randomly stratified, cluster-sampling scheme. All potential investigators had received training on the objectives of the study, how to administer the questionnaire, the standard methods of measurement, the importance of standardization, and study procedures Those who earned a perfect score on a post-training test were allowed to participate as study investigators. According to the American Heart Association, blood pressure (BP) was measured three times at two-minute intervals after at least five minutes of rest using a standardized automatic electronic sphygmomanometer (HEM-907; Omron, Kyoto, Japan). The age- and gender-specific prevalences of AF among participants with both normal SUA levels and hyperuricemia were calculated, and univariate and multivariate logistic regression analyses were performed to estimate the crude and independent association between SUA and the presence of AF. Data are expressed as odds ratio (OR) and 95 % confidence interval (CI), mean ± standard deviation, or frequency and percentage; a P < 0.05 was considered as statistically significant
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
