Association between HOMA-IR and Lung Function in Korean Young Adults based on the Korea National Health and Nutrition Examination Survey

Young Bok Lee,Jae Yen Song,Jae-Im Lee,Tae Seo Sohn,Hyo-Suk Ahn,Tae-Kyu Lee,Hee Yeon Kim,Chang Dong Yeo,Mihee Hong,Hiun Suk Chae,Kyungdo Han,Seong Cheol Jeong,Dong-Hee Lee,Young Soo Kim

doi:10.1038/s41598-017-11337-3

Young Bok Lee, Jae Yen Song + Show 12 more

Open Access

https://doi.org/10.1038/s41598-017-11337-3

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Abstract

Metabolic syndrome, including obesity and insulin resistance, has been reported to lower lung function in elderly subjects with asthma or chronic obstructive lung disease. This study aimed to find the association between lung function and insulin resistance in Korean young adults. This study used data from the Korean National Health and Nutrition Examination Survey 2011–2013, which is a representative sample of the Korean population. A total of 1,922 young adults aged 19 to 40 were included in the analysis. The association between lung function test and insulin resistance was evaluated. Weighted logistic regression analyses showed a significant negative correlation of insulin resistance with FVC% predicted (correlation coefficient γ = −0.130, P < 0.0001), FEV1% predicted (γ = −0.074, P = 0.004) and FEV1/FVC ratio (γ = −0.059, P = 0.019) in young adults, especially in subjects without asthma (γ for FVC% predicted, FEV1% predicted and FEV1/FVC ratio = −0.138, −0.092, and −0.061, respectively). This study demonstrates an inverse correlation between insulin resistance and lung function in Korean young adults. Young adults with preclinical insulin resistance have a higher risk of impaired lung function.

Highlights

A negative correlation between lung function and metabolic syndrome has recently been proposed in several studies
Paek et al reported that Korean patients with chronic obstructive pulmonary disease (COPD) had higher risk of metabolic syndrome; glucose level was not associated with low lung function[6]
We divided subjects into two groups according to the presence of asthma that might affect lung function test using the data from the 2011–2013 Korean National Health and Nutrition Examination Survey (KNHANES V-2, V-3, and VI-1)

Summary

Introduction

A negative correlation between lung function and metabolic syndrome has recently been proposed in several studies. A component of metabolic syndrome, was reported as a risk factor for decreased pulmonary function in asthma patients[2,4]. Yamamoto et al reported that impaired lung function was associated with higher risk of metabolic syndrome independent of insulin in middle aged Japanese population[5]. Paek et al reported that Korean patients with chronic obstructive pulmonary disease (COPD) had higher risk of metabolic syndrome; glucose level was not associated with low lung function[6]. In another Korean study, Park et www.nature.com/scientificreports/. This study demonstrates the association between preclinical low lung function and subclinical insulin resistance in a healthy population

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