Abstract
This study aimed to investigate the association between HLA genotypes and antiepileptic drug-induced cutaneous adverse reactions (AEDs-cADRs) among patients with epilepsy in Ningxia Hui Autonomous Region of Northwest China. Fifteen patients with AEDs-cADRs and 30 matched AEDs tolerant controls from anested case-control study were tested the HLA-A, HLA-B, and HLA-DRB1 genotype using the polymerase chain reaction sequence-based typing (PCR-SBT). Significant difference was not observed between AEDs-cADRs and AEDs tolerant groups in terms of HLA-A, HLA-B, and HLA-DRB1 genotype frequencies. Future studies using larger cohorts are needed to verify this observation.
Highlights
Cutaneous adverse drug reactions are common adverse reactions observed in patients using antiepileptic drugs (AEDs)
Twelve patients were of Han ethnicity and three of Hui ethnicity
Ten patients were with generalized epileptic seizures and five were with partial epileptic seizures
Summary
Cutaneous adverse drug reactions (cADRs) are common adverse reactions observed in patients using antiepileptic drugs (AEDs). Studies have demonstrated that the incidence of AEDs-cADRs was about 3.61%. CADRs are relatively common with the use of aromatic antiepileptic drugs (AAEDs), including carbamazepine (CBZ), phenytoin (PHT), lamotrigine (LTG), and phenobarbital (PB) [1]. They manifest as ordinary maculopapular eruption (MPE), eventually leading to serious life-threatening conditions such as hypersensitivity syndrome (HSS), Steven-Johnson syndrome (SJS), or toxic epidermal necrolysis (TEN). AEDs-cADRs often lead to drug discontinuation in patients with epilepsy, resulting in the inability to control seizures.
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