Abstract
We have studied the HLA associations of MS patients in Arab patients from two regions. Those patients from the Mediterranean area showed an association of MS with HLA-DR2 (p less than 0.001) and -DQw1 (p less than 0.05), whilst in those from the Gulf there was an association with -DRw53 (p less than 0.02). In the Mediterranean patients -DRw52 was negatively associated with MS (p less than 0.05). In the control populations from the two regions there was a considerable variation in the incidence of HLA antigens. Thus, Gulf Arabs had an increased incidence of -DR1 (p less than 0.05), -DR2 (p less than 0.02), -DR6 (p less than 0.05) and decreased incidence of -DR5 (p less than 0.05), -DRw52 (p less than 0.02) and -DQw3 (p less than 0.01) compared to the Mediterranean control population. These findings are discussed in relation to the aetiology of the disease.
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