Abstract

Background: HIV-associated neurocognitive disorders (HAND) are characterized by impairment in at least two cognitive domains with a prevalence of up to 50% in people living with HIV (PLHIV). HAND is subdivided into asymptomatic neurocognitive impairment (ANI), mild neurocognitive disorder (MND) and HIV-associated dementia (HAD). Objectives: Demonstrate the impact of HAND and possible pathogenic mechanisms by relating them to the prevalence of subtypes Design and Setting: Review of the literature. Methods: Review made from PubMed with the descriptors “neurocognitive disorder”, “HIV”, “review”. Twelve articles were selected, among systematic reviews and meta-analysis published since 2017. Results: Before Highly Active Antiretroviral Therapy (HAART) HAD cases had a higher prevalence, probably due to the high viral load causing intense brain inflammation. Today the percentage of HAD has decreased, but the cases of ANI and MND continue to increase. HAART increases life expectancy and reduces viral load, but it may be related to the increase in ANI / MND associated with early brain aging and mild inflammatory processes resulting from primary infection. Conclusions: HAND is a concern for its impact on the quality of life and life expectancy of PLHIV. Therefore, neuropsychological assessment is an important tool for early diagnosis and disease management. The change in prevalence of different HAND subtypes raises doubts about the pathogenesis of these conditions and further studies are needed to elucidate this issue and develop therapeutic solutions.

Highlights

  • Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack

  • The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells

  • Conclusion: the analyzed data indicate that the polymorphisms contributed to the susceptibility to Parkinson’s disease (PD), further studies related to the polymorphisms and their relationship to PD are still needed for more ethnic groups, and early diagnosis is possible

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Summary

Introduction

Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Methods: A literature review and an observational, descriptive and transversal data collect on treatment for acute demyelinating polyradiculoneuritis, available at DATASUS from January 2008 to December 2020, and articles available at Scielo and PubMed. Results: There were 7,917 hospitalizations, representing a total expenditure of R$ 9,392,552.04, 2009 being the year with the highest number of hospitalizations (809) and 2017 with the highest amount spent during the period (R$ 967,284.65). Methods: A literature review and an observational, descriptive and transversal data collect on surgical treatment was carried out, available from January 2008 to December 2020 and articles available in Scielo, Lilacs and PubMed. Results: There were 15,148 hospitalizations for surgical procedures for the treatment of chronic subdural hematoma, representing a total expenditure of R$ 45,365,258.21, with 2018 being the year with the highest number of hospitalizations (1,418) and with the highest amount spent during the period (R$ 4,570,334.28). Conclusions: The “Coca-Cola Bottle sign” is a classic sign of Graves’ disease, some signs, such as, unilateral and single orbital musculature involvement, may be suggestive of involvement by other etiologies, suggesting the benefit of an early expanded investigation

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