Association Between High Levels of Hepatitis B Core Antibody and Seroclearance of Hepatitis B e Antigen in Individuals With Chronic Hepatitis B Virus Infection

Jessica Liu,Hui-Han Hu,Chia-Ling Chang,Chin-Lan Jen,Mei-Hsuan Lee,Sheng-Nan Lu,Li-Yu Wang,Quan Yuan,Ning-Shao Xia,Masaya Sugiyama,Nao Nishida,Masashi Mizokami,Chien-Jen Chen,Pei-Jer Chen,Hwai-I Yang

doi:10.1016/j.cgh.2018.09.037

Association Between High Levels of Hepatitis B Core Antibody and Seroclearance of Hepatitis B e Antigen in Individuals With Chronic Hepatitis B Virus Infection

Jessica Liu, Hui-Han Hu + Show 13 more

https://doi.org/10.1016/j.cgh.2018.09.037

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Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association	Publication Date: Sep 26, 2018
Citations: 9

Affiliation: Genomics Research Center, Academia Sinica, Chang Gung Memorial Hospital, Xiamen University, National Center for Global Health and Medicine, Nagoya City University, Academia Sinica, National Taiwan University, National Taiwan University Hospital, National Yang Ming University Hospital, National Yang Ming Chiao Tung University

#Hepatitis B E Antigen #Higher Serum Alanine Aminotransferase + Show 8 more

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Abstract

For chronic hepatitis B patients, hepatitis B e antigen (HBeAg) seroclearance signals a transition from an immunologically active phase to an inactive carrier state with a reduction in hepatitis B virus (HBV) DNA levels and a reduced risk of hepatocellular carcinoma (HCC).1 Predictors of HBeAg seroclearance include lower HBV DNA levels, viral genotype, the precore mutation, and higher serum alanine aminotransferase (ALT) levels.2.

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