Abstract
The correlation between hepatitis B virus (HBV) infection and metabolic syndrome (MetS) remains to be clarified. In this study, we explored this association in a large population in Southwest China. This was a cross-sectional study, with pooled adult health data. Multivariate logistic regression analysis, controlling for age, sex, HBV status, alanine aminotransferase, and fatty liver, was used to identify predictor(s) of MetS. Of the 96,175 participants, positive HBV was identified in 7984 (8.30%) and MetS in 12,092 (12.57%). The MetS prevalence was lower among HBV positive than negative individuals (11.64% versus 12.66%, P < 0.001). The adjusted odds (aOR) of positive HBV among individuals with MetS was 0.841 (95% confidence interval (CI), 0.771–0.916) in men and 0.834 (95% CI, 0.672–0.925) in women. Elevated triglyceride level, a component of MetS, was inversely associated with HBV status in both men and women: aOR, 0.551 (95% CI, 0.514–0.590) and 0.683 (95% CI, 0.605–0.769), respectively. Among HBV positive individuals, liver cirrhosis was more common among those with than without MetS (4.83% versus 2.93%, respectively; P = 0.002). HBsAg-seropositive are inversely associated with MetS, especially elevated triglycerides. Liver cirrhosis was more common among HBV infection patients with MetS.
Highlights
metabolic syndrome (MetS) refers to diseases caused by metabolic disturbances, such as increased waist circumference, hyperglycemia, elevated blood pressure (BP), and dyslipidemia
A study performed at a university health center in a North Taiwan province reported that anti-HBc(+) hepatitis B virus (HBV) infection was associated with a higher risk for MetS19
The body mass index (BMI) and waist circumference measurements were higher among individuals with than without HBV infection, while levels of total cholesterol, HDL cholesterol, and triglyceride were lower (P < 0.05)
Summary
MetS refers to diseases caused by metabolic disturbances, such as increased waist circumference, hyperglycemia, elevated blood pressure (BP), and dyslipidemia. An association between MetS and non-alcoholic fatty liver disease (NAFLD), chronic hepatitis C (CHC) and HCC has previously been demonstrated. It is widely confirmed that chronic hepatitis C virus infection may increase the risk of insulin resistance and type 2 diabetes. The relationship between HBV infection and MetS has been explored in several studies, with six of these studies focusing on Asian populations, and two on American populations. The relationship between HBV infection and MetS has been explored in several studies, with six of these studies focusing on Asian populations, and two on American populations10,11 Despite this body of research, the correlation between HBV infection and MetS remains unclear. A study performed at a university health center in a North Taiwan province reported that anti-HBc(+) HBV infection was associated with a higher risk for MetS19. Our aim in this study was to evaluate the association between HBV infection and MetS, and the individual components of MetS, in China, where the public health burden of HBV infection is high, with an estimated 93 million cases of HBV infection and an endemic rise in MetS
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