Association between Helicobacter pylori and Diabetes Mellitus

Abstract

Background: H. pylori is a gram-negative, spiral shaped, Microaerophile pathogenic bacterium that specifically colonizes on the gastric epithelium, it is one of the most common human bacterial pathogens and is the main etiological factor for peptic ulcer disease, simple gastritis and gastric malignancy. The immune status of diabetic patients is compromised, which may lead to an increased susceptibility to H. pylori infection. The aim of this study is to assess Association between Helicobacter pylori and Diabetes Mellitus.
 Methods and Material: This was a cross-sectional study with 102 diabetic patients (both IDDM and NIDDM). H.pylori was assessed through the determination of stool antigen by Immunochromatography.
 Results: Out of 102 samples were collected from diabetic patients, 58 were male and 44 were female. 52.9% of them are positive for H.pylori and 47.1% are negative. The mean ages of H.pylori positive patients were 44.01 years where the mean age of negative patients were 42.47 years. There was a statistically significance association (p=0.007) between the diabetes and H.Pylori infection, also there was association between history of GIT disorder and H. pylori infection, between smoking and H. pylori infection.
 Conclusion: The study showed that Helicobacter pylori infection was significantly higher in diabetes Mellitus.
 Keywords: H.pylori, Diabetes Mellitus, T1DM, T2DM