Abstract
Background:Poor functional status can significantly affect Health-Related Quality of Life (HRQoL) of HIV patients. However, there is scarce information on the functional profile of such patients before starting antiretroviral therapy (ART).Objective:To estimate the association between health-related quality of life and physical functioning in Antiretroviral-Naive HIV-infected patients.Methods:We conducted a cross-sectional study with HIV-infected patients older than 18 years, and naïve to antiretroviral therapy. The patients were evaluated for functional profile by pulmonary function (forced vital capacity, forced expiratory volume at one second, and Tiffeneau index), handgrip strength, and six-minute walk test in a cross-sectional study. HRQoL was evaluated by the 36-Item Short-Form Health Survey and its Physical (PCS) and Mental (MCS) Component Summaries. Multiple linear regression analyses were used to evaluate the association of predictor variables with PCS and MCS scores.Results:We found lower HRQoL among females patients, with far below average impairment of mental health component. Both male and female patients presented lower 6MWD function test values. Patients with dynapenia were older than patients without it, presented lower PCS mean score, lower family income, poor 6 MWD function test, lower FVC, and lower FEV1 t. Multivariable logistic regression analyses showed that Grip Strength, age and family income were predictor variables for Physical component of HRQoL. Female gender and smoking habit were predictive for the mental component of HRQoL.Conclusion:HRQoL in HIV, drug-naïve patients is predicted by level of dynapenia, smoking, income and gender. Therefore, lifestyle changes and active exercising can help to improve HRQoL in such patients.
Highlights
HIV+/AIDS patients on successful Antiretroviral Therapy (ART) present increased life expectancy
Patients with dynapenia were older than patients without it, presented lower Physical Component Summary (PCS) mean score, lower family income, poor 6 MWD function test, lower forced vital capacity (FVC), and lower FEV1 t
Multivariable logistic regression analyses showed that Grip Strength, age and family income were predictor variables for Physical component of Health-Related Quality of Life (HRQoL)
Summary
HIV+/AIDS patients on successful Antiretroviral Therapy (ART) present increased life expectancy. HIV-infected individuals still have a higher mortality risk when compared to the uninfected population, in consequence of non-AIDS related health problems [2]. The prevalence of HIV/AIDS is continually growing. Recent data revealed that 36.7 million people in the world are living with HIV and 18.2 million people are currently on antiretroviral therapy. In Brazil, approximately 830,000 individuals are infected with HIV, and 41,100 new cases are reported each year [3]. Poor functional status can significantly affect Health-Related Quality of Life (HRQoL) of HIV patients. There is scarce information on the functional profile of such patients before starting antiretroviral therapy (ART)
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