Abstract
The incidence of thyroid cancer (TC) is increasing although explanatory causes are lacking. A link between cancer and inflammation is well documented but unclear for autoimmune thyroid diseases and TC. We aimed to systematically review the association between Hashimoto's thyroiditis (HT) and papillary, follicular, medullary, anaplastic thyroid carcinoma, and thyroid lymphoma (TL). PubMed, OVID Medline, Google Scholar, and the Cochrane Library were searched from 1955 to 2016. The inclusion criteria were age >18 years, ≥20 cases of HT or TC. We collectively examined the incidence of HT in TC and of TC in HT. We identified 36 studies (64,628 subjects) published between 1955 and 2016 from 13 countries. We found a relative risk (RR) of HT among papillary thyroid cancer (PTC) of 2.36 [95% confidence intervals (CIs) 1.55-3.29, p < 0.001], an RR of PTC among HT of 1.40 (95% CI 1.07-1.85, p = 0.016), and an RR of TL among HT of 9.74 (95% CI 3.93-24.13, p < 0.001). We report an association between HT and PTC and between HT and TL. No association was found between HT and follicular, medullary, or anaplastic thyroid cancer.
Highlights
Thyroid cancer (TC) is the most common endocrine malignancy, and the incidence has been increasing worldwide during the last decades [1,2,3,4,5]
We found a relative risk (RR) of Hashimoto’s thyroiditis (HT) among papillary thyroid cancer (PTC) of 2.36 [95% confidence intervals (CIs) 1.55–3.29, p < 0.001], an RR of Papillary thyroid carcinoma (PTC) among HT of 1.40, and an RR of Thyroid lymphoma (TL) among HT of 9.74
We present the first systematic review on the association between HT and five types of TC, and the largest review on HT and PTC examining both HT and TC patient groups
Summary
Thyroid cancer (TC) is the most common endocrine malignancy, and the incidence has been increasing worldwide during the last decades [1,2,3,4,5]. Papillary thyroid carcinoma (PTC) (70–80% of all TCs), follicular thyroid carcinoma (FTC) (10–20% of all TCs), medullary thyroid carcinoma (MTC) (5–8% of all TCs), and anaplastic thyroid carcinoma (ATC) (
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