Association between GSTM1, GSTT1 gene polymorphisms and asthma in adult patients from Tikrit population of Iraq

Abstract

Introduction and Aim: Asthma is known as a polygenic and multifactorial disease. The underlying debate about the role of genetics in the development of asthma is still unclear. The objectives of this research are to examine whether the GSTM1 and GSTT1 gene polymorphisms are associated with asthma susceptibility. Materials and Methods: A total of 70 patients with asthma and 20 healthy individuals were investigated in this study. Genotyping was carried out by using PCR protocol for analysis of GSTM1 and GSTT1 null/positive genotypes. Results: Patients with asthma (34.285%) demonstrated a greater prevalence of the GSTM1, GSTT1 (-) genotype than the healthy subject (10%, P-value 0.012). A positive correlation was found between GSTT1, GSTM1 (+) genotype and healthy individuals (40%) compared with asthmatic patients (24.285%). Conclusion: The results of this research support the idea that GSTM1, GSTT1 (-) genotype may play critical roles in asthmatic inflammatory response. Further experimental investigations are needed to estimate the role of GSTM1 and GSTT1 polymorphisms in asthma.