Association between group G chromosomes, especially chromosome G21, and susceptibility of human cells to coxsackie B viruses

Abstract

The R method of differential staining of chromosomes by length was used for a comparative study of karyotypes of human cells of the J-96 strain and the J-41 cell line obtained from it, which is specifically resistant to Coxsackie B viruses. It was shown with a high degree of statistical significance (P<0.0001) that the G21 chromosome was eliminated from the chromosome sets of the resistant cells. The number of other chromosomes in individual cells of the cultures varied, but they were constantly present in most cells of both lines tested. It is concluded that the susceptibility of human cells to Coxsackie B viruses is mainly linked with the G21 chromosome.