Abstract
ObjectivesCloninger developed the three‐dimensional personality theory and Tridimensional Personality Questionnaire (TPQ), which shows that some dimensions of personality traits are heritable and related to neurotransmitters including dopamine. glutathione peroxidase 1 (GPx1) plays an important role in metabolic dopamine change and closely relates to neurological and psychiatric disorders. The impact of GPx‐1 polymorphisms has been rarely explored in the field of personality traits. We decide to explore the relationships between them in healthy Chinese‐Han subjects by using the polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP).MethodsIn our study, 493 healthy Chinese‐Han participants (male = 234, female = 259) were recruited. 2 ml of EDTA‐treated blood from each volunteer was taken; meanwhile, personality traits were assessed by TPQ. We detected the genotypes of selected two polymorphisms through PCR‐RFLP after extracting DNA. Finally, the association between different genotypes and TPQ scores was performed using SPSS, p < .05 is seen as significant statistical significance.ResultsOur data found a correlation between rs1800668 and novelty seeking (NS) subscale NS2 (X 2 = 7.392, p = .025). While the results showed the rs1050450 was significantly associated with NS4 (X 2 = 6.059, p = .048). Regarding sex stratification, there was a significant difference in the NS2 score (X 2 = 8.232, p = .016) among women for rs1800668. No sex effect was observed for either genotype for rs1050450.ConclusionGPx‐1polymorphism is related to personality traits in healthy Chinese‐Han subjects. Our results suggested that GPx‐1 may be involved in the biological mechanisms and be a potential gene that influenced personality.
Highlights
Personality traits determine the basic behaviors of the individual, which are the relatively stable and persistent tendencies of the individual to act in certain ways
The results indicated that the glutathione peroxidase (GPx)-1 polymorphisms rs1050450 and rs1800668 were associated with the personality trait novelty seeking (NS)
Our results suggested that GPx-1 may be a potential gene that influenced personality
Summary
Personality traits determine the basic behaviors of the individual, which are the relatively stable and persistent tendencies of the individual to act in certain ways. These traits, the core component of personality, can reduce personal volatility and lead to undertaking specific and effective actions. The three dimensions are associated with three neurotransmitters, dopamine (DA), serotonin (5-HT), and norepinephrine (NA) (Cloninger 1987; Cloninger 1988)(Cloninger 1987, Cloninger 1988). Subsequent work reported in the midbrain low D2/3 receptor (D2/3–R) availability, which is associated with elevated DA release in the striatum, could predict impulsivity by using PET(Buckholtz et al 2010). A similar conclusion from PET studies(Farde et al 2018)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
