Abstract
Impaired lipid metabolism in diabetic patients can lead to cardiovascular complications. Poor glycaemic control is associated with a significant increase in the risk of both patient’s morbidity and mortality. An early intervention to regulate circulating lipids has been found to lower the risk of cardiovascular problems and death. Glycated hemoglobin (HbA1c) is a reliable indicator of rising blood sugar levels. This hospital based observational study was conducted in the Department of Medicine, Sher-E-Bangla Medical College Hospital, Barisal from October 2014 to March 2015 over a period of 6 month to determine the correlation of glycemic control and lipid profile in patients with type 2 diabetes. A total of 110 type 2 diabe- tes mellitus(DM) patients of both sexes admitted to the Deapartment of Medicine of Sher-E- Bangla Medical College Hospital, Barisal, were recruited for this study. Following standard procedures and protocols, fasting blood sugar (FBS), blood sugar two hours after breakfast, Glycosylated Hemoglobin (HbA1c) and fasting lipid profile were measured. The age of respondents ranged from 34 to 70 years with the mean age of 54.35}8.02 years. Among the patients male were 70 (63.6%) and female were 40 (36.4%). Mean age at diagnosis of DM and duration of DM was 47.07}6.03 years and 7.27}3.41 years, respectively. Mean body mass index (BMI), FBS and HbA1c were 25.02}5.22 kg/m2, 8.06}2.01 mmol/L and 8.34}1.9 % respectively. Significant positive correlation of HbA1c and FBS with BMI, total cholester- ol(TC), triglyceride(TG), low density lipoprotein(LDL-C) and negative correlation with high density lipoprotein (HDL-C) was found. Significantly higher TC, TG and LDL-C and lower HDL-C were found in poor glycemic control (HbA1c ≥ 7) group than good glycemic control (HbA1c < 7 ) group. The results of this study showed that , higher levels of glycemic parame- ters are significantly associated with dyslipidemia. These findings also indicate that HbA1c can be utilized for screening of high risk diabetic patients for early diagnosis of dyslipidemia and timely intervention with lipid lowering drugs. BSMMU J 2021; 14(4): 138-143
Highlights
Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycaemia affecting about 347 million people worldwide.[1]
Epidemiological studies have demonstrated that diabetes mellitus is an independent risk factor for cardiovascular disease and it amplifies the effects of other common risk factors such as smoking, hypertension and dyslipidemia.[6]
Significant positive correlation of HbA1c was found with body mass index (BMI), Total Cholesterol (TC), TG, LDL-C and negative correlation with HLD-C (Table-II)
Summary
Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycaemia affecting about 347 million people worldwide.[1]. Very few studies have been conducted so far, in our community and in the world, to assess the impact of HbA1c with parameters of serum lipid profile values in type 2 diabetic subjects. If strong impact of long term glycemic control on lipid profile parameters could have been established, HbA1c could be used as dual biomarker This will help clinician to assess glycemic and lipid profile status and to predict long term complications by measuring HbA1c alone in type 2 diabetic subjects. This study was conducted to see the correlation between glycaemic control and serum lipid profile in type 2 diabetic patients and to evaluate the utility of glycated haemoglobin (HbA1c) as an indirect marker of dyslipidaemia
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