Association Between Glucose-to-Lymphocyte Ratio and Short-term Mortality in Critically Ill Subarachnoid Hemorrhage Patients: a Retrospective Cohort Study

Abstract

ObjectiveWe aimed to evaluate the association between admission glucose-to-lymphocyte ratio (GLR) and 28-day all-cause mortality in critically ill patients with non-traumatic SAH. MethodsData were extracted from the Medical Information Mart for Intensive Care IV database. The primary outcome was 28-day all-cause mortality. Cox regression analysis, Kaplan-Meier curves, restricted cubic spline curves, subgroup analysis and sensitivity analysis were used to assess the relationship between GLR and patient outcome. ResultsA total of 530 patients were included in this study. The Kaplan-Meier curves demonstrated that SAH patients in the high-GLR group (GLR ≧7.4) had a lower 28-day survival rate. A linear relationship was found between GLR and 28-day mortality. Multivariable Cox regression revealed that admission GLR was independently associated with 28-day mortality in critically ill SAH patients (hazard ratio [HR]=1.03, 95% confidence interval [CI] = 1.01-1.06, P = 0.011). SAH patients in the high-GLR group had a higher risk of 28-day mortality, compared with those in the low-GLR group (HR=1.62, 95% CI = 1.10-2.37, P = 0.015). Subgroup and sensitivity analyses supported the robustness of our results. ConclusionHigh GLR levels at admission were associated with increased 28-day all-cause mortality in critically ill SAH patients.