Association between ghrelin and triglyceride levels in Blacks with and without type 2 diabetes (1029.5)

Abstract

This cross sectional study examined the association between ghrelin and triglyceride levels in Haitian and African Americans with (n= 258) and without (n=239) type 2 diabetes. Participants were recruited from multiple sources from Miami‐Dade and Broward Counties, Florida. Fasting blood samples were collected and ghrelin was analyzed from whole blood using Enzyme Immunometric Assay. Serum triglyceride levels were assayed by enzymatic methods. Dietary variables were collected using the Willett’s food frequency questionnaire, and Healthy Eating Index 2005 (HEI‐05) scores were calculated. Analyses included descriptive statistics, Pearson’s correlations and linear regressions. Participants with type 2 diabetes had significantly lower ghrelin (P<0.001) and higher triglyceride levels (p=0.023) as compared to those without type 2 diabetes. Ghrelin was inversely correlated with triglyceride levels in participants with type 2 diabetes (P=0.021). Linear regression analysis indicated that after controlling for covariates, the association between lnghrelin and lntriglycerides was only significant for participants with type 2 diabetes (β=‐.181, SE=.042, P=0.003). Findings of this study suggested a potential role of ghrelin as a biomarker of cardiovascular disease risk in Blacks with type 2 diabetes.Grant Funding Source: Supported by NIH/NIDDK sponsored grant.