Abstract
Apolipoprotein C3 (APOC3) is an important regulator of lipoprotein metabolism, and has been shown to be strongly associated with hypertriglyceridemia. We tested whether triglyceride-influencing genetic variants at APOC3 (T-455C, C-482T, C1100T, and SstI) are associated with the onset of hypertension (HTN) among Korean adults stratified by lifestyle-related factors in the Ansung–Ansan cohort within the Korean Genome and Epidemiology Study. After excluding participants with preexisting cancer, cardiovascular diseases, diabetes, and HTN, a total of 5239 men and women were included at baseline (2001–2002), and followed up for a median of 9.8 years. Carriers of the C allele of C1100T with body mass index <25 kg/m2 showed a significantly lower HTN risk (hazard ratio (HR) than non-carriers: 0.87, 95% confidence interval (CI): 0.77–0.98) after adjusting for covariates. In addition, carriers of the C allele of T-455C and the T allele of C-482T with low physical activity had lower incident HTN than non-carriers (HR: 1.14, 95% CI: 1.03–1.26; HR: 1.13, 95% CI: 1.02–1.25). Our results suggest that genotype effects in APOC3 on HTN risk have been shown in lean carriers of the C allele of C1100T and in less active people having the C allele of T-455C and T allele of C-482T in a large sample of the Korean population.
Highlights
Hypertension (HTN) is one of the factors contributing to the morbidity and mortality associated with cardiovascular disease (CVD) [1]
Among the risk factors affecting HTN incidence, several previous cross-sectional [4,5] and prospective observations [6,7] reported that lipid phenotypes characterized by increased triglyceride (TG) and decreased high-density-lipoprotein (HDL) cholesterol are associated with HTN risk
It has been speculated that disorders of lipoprotein metabolism might lead to endothelial dysfunction, altered nitric oxide production [8], structural changes in large arteries following atherosclerosis [9], and an overstimulated renin–angiotensin–aldosterone system induced by concomitant insulin resistance [10]
Summary
Hypertension (HTN) is one of the factors contributing to the morbidity and mortality associated with cardiovascular disease (CVD) [1]. HTN prevalence has been continuously increasing, and the. 2016 Korean National Health and Nutrition Survey reported that individuals having HTN accounted for 29.1% of the Korean adult population aged ≥30 years [2]. Hypertension is a complex disease with strong interaction between genetic susceptibility and environmental factors [3]. Among the risk factors affecting HTN incidence, several previous cross-sectional [4,5] and prospective observations [6,7] reported that lipid phenotypes characterized by increased triglyceride (TG) and decreased high-density-lipoprotein (HDL) cholesterol are associated with HTN risk. ApoC3 can inhibit the catabolism of Nutrients 2018, 10, 1595; doi:10.3390/nu10111595 www.mdpi.com/journal/nutrients
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