Abstract
Objective To investigate the relationship between RXRG rs1467664 and genetic susceptibility to type 2 diabetes mellitus. Methods A case-control study was used. Genotypes of RXRG rs1467664 in 1092 patients with type 2 diabetes mellitus and 1092 normal controls was detected by SNPscan™. Genotype and allele frequencies were analyzed by SPSS 20.0 software. Results There was no significant difference in allele frequency and genotype frequency of RXRG rs1467664 between case and control groups. Before and after adjusting for age, gender, and BMI, there was no statistically significant difference in rs1467664 in genetic models between the two groups (P>0.05). Conclusion Our result suggested that there is no significant association between RXRG rs1467664 and genetic susceptibility to type 2 diabetes mellitus in Guangdong Han population. Key words: Type 2 diabetes mellitus; Single nucleotide polymorphism; RXRG gene
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