Association between genetic polymorphisms of (Cu/ZnSOD and CAT C262T) and the risk of breast cancer

Abstract

In a number of malignancies, oxidative stress plays a role. SOD is an endogenous antioxidant enzyme that aids in the reduction of oxidative stress. The goal of this study was to see how the polymorphisms in the Cu/Zn SOD (rs2070424) and CAT C-262 T (rs1001179) genes affected breast cancer susceptibility. The current findings indicated that there was no significant difference between the patients and controls in the rs2070424 SOD1 SNPs. We discovered that heterozygous A/G had a higher genotypic frequency than homozygous A/A (OR = 1.0000, 95 % CI = 0.2403–4.1607, P = 1.00). and the homozygous variation G/G genotypic frequency compared to homozygous A/A (OR = 0.4331, 95% CI = 0.0084–22.3896, P = 0.6776). In the SOD1 A215G polymorphism, there were no significant variations in G allele frequencies between patients and controls (OR = 1.00, 95% CI: 0.2497–4.0055, P = 1.00). There was no significant link between the SOD1 A215G polymorphism and breast cancer susceptibility, according to our data. We also discovered that heterozygous C/T had a higher genotypic frequency than homozygous C/C (OR = 22.20, 95% CI = 1.287to 382.71, P = 0.0328). and the homozygous T/T genotypic frequency compared to homozygous C/C (OR = 1.48, 95% CI = 0.270–8.19, P = 0.64). But in the CAT C-262 T polymorphism, there was a significant difference in T allele frequencies between patients and controls, that's mean strong relation between the catalase enzyme CAT 262 T (rs1001179) gene and the development of breast cancer (OR = 3.50, 95% CI: 1.1701–10.4, P = 0.0250).