ASSOCIATION BETWEEN GAMMA GLUTAMYL TRANSFERASE AND METABOLIC SYNDROME IN YOUNG ADULTS IN EASTERN INDIA: AN OBSERVATIONAL STUDY

Abstract

Introduction: Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma glutamyl transferase (GGT) are the principal hepatic enzymes in clinical laboratory setup. ALT and AST are elevated in various types of hepatitis, cirrhosis and hepatic neoplasia. GGT is usually elevated in alcoholism. Recently, in some studies, the elevation of GGT has been observed in metabolic syndrome. Objective: To study the relationship of gamma glutamyl transferase (GGT) with Metabolic Syndrome (MS) in a population. Materials and Methods: 91 MS patients and 94 age and sex matched control individuals were recruited into the study, after obtaining their voluntary informed consent. Serum GGT levels along with other biochemical parameters of all the participants were compared statistically Results: Serum GGT level was significantly higher in MS group than in non MS group (p = 0.007).Conclusion: MS contributed towards higher GGT level in our study population.Key words: Metabolic Syndrome (MS), Gamma glutamyltransferase (GGT), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST).