Abstract
Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. To investigate the association of FTO gene with adiposity markers in Chilean adults. 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2 [95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.
Highlights
Numerous studies have identified the role of Fat-mass-associated-gene
409 participants were included in this cross-sectional study
fully adjusted model showed a significant association between FTO genotype and body weight
Summary
Fanny Petermann1,a,f,*, Marcelo Villagrán2,b,g,*, Claudia Troncoso3,a, Lorena Mardones2,b,g, Ana María Leiva4,c,f, María Adela MartÍnez5,b,f, Alex Garrido-Méndez6,d,g, Felipe Poblete-Valderrama7,d,f, Carlos Salas-Bravo8,d,f, Robinson Ramírez-Vélez9,e,g, Natalia Ulloa10,b,f,g, Francisco Pérez-Bravo11,b,g, Carlos Celis-Morales1,12,d,g (En representación de todos los integrantes del grupo ELHOC, Epidemiology of Lifestyle and Health Outcomes in Chile). Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.