Abstract
Sugars, and in particular fructose, consumption has been associated with increased systolic and diastolic blood pressure (BP), mediated by increased serum uric acid concentration, which interferes with the renin‐angiotensin mechanism and inhibits nitric oxide release from endothelial cells. Uric acid can also increase sodium sensitivity.Investigating associations between dietary sugars and health endpoints is difficult because of measurement error in self‐reported intake. Dietary biomarkers may help us elucidate true associations.We have assessed total sugars and total fructose intake (including fructose from sucrose) in a cross‐sectional analysis of 1366 participants (624 men, 742 women), 39 – 77 years of age, of the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC) study using 7‐day diaries and sucrose and fructose measured in spot urines, as biomarkers of sugars intake. Other study measurements include serum uric acid and BP. Associations were investigated using linear regression analyses with log‐transformed variables, stratified by sex and adjusted for age and BMI. Urinary concentrations were adjusted by specific gravity.Total sugars consumption (mean ± SD) was 111.7 ± 40.3 g/d, of which 44.3 ± 17.9 g/d was total fructose. Serum uric acid was 344 ± 66 µM. Serum uric acid concentration was not associated with systolic BP in men and women. Intake of total sugars and total fructose assessed by 7‐d diary or biomarker was not significantly associated with serum uric acid or with BP.Our results do not support an association between fructose intake and increased BP. Adjusted (age, BMI) systolic BP mm Hg (mean, 95% CI) by quintile of total fructose intake in 624 men and 742 women of EPIC Norfolk. Intake was measured by biomarker (urinary fructose) and 7DD (adjusted for total energy intake). Men (n=624) Women (n=742) Intake Biomarker 7DD Biomarker 7DD Q1 137.4 (136.3; 138.6) 136.9 (135.9; 138.0) 132.2 (131.0; 133.5) 131.2 (129.9; 132.6) Q2 136.7 (135.6; 137.8) 137.1 (135.8; 138.3) 132.7 (131.4; 134.0) 131.8 (130.5; 133.1) Q3 136.9 (135.7; 138.0) 137.1 (135.9; 138.3) 132.5 (131.3; 133.8) 133.5 (132.2; 134.8) Q4 137.4 (136.2; 138.5) 136.8 (135.6; 138.1) 132.3 (131.0; 133.6) 132.2 (130.8; 133.5) Q5 137.0 (135.8; 138.2) 137.5 (131.7; 132.9) 131.8 (130.3; 133.2) 132.9 (131.7; 134.0)
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
