Abstract
EC McGowan, X Hong, J Selhub. J Allergy Clin Immunol Pract. 2020;8(1):132–140.e5 Food allergy (FA) prevalence has increased within the past decades. Prior studies have postulated an association between folate exposure and the development of allergic disease. Folate is a water-soluble B vitamin involved in DNA methylation, a process that leads to heritable changes in gene expression. The principal folate involved in DNA methylation is 5-methyltetrahydrofolate (5-MTHF). Unmetabolized folic acid (UMFA) appears in circulation when the enzyme dihydrofolate reductase (DHFR), which converts folic acid to tetrahydrofolate, is saturated. The current study is the first to examine the association between UMFA and 5-MTHF and the …
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