Association between Fasting Glucose Concentration, Lipid Profile and 25(OH)D Status in Children Aged 9⁻11.

Lukasz Szternel,Magdalena Krintus,Katarzyna Bergmann,Tadeusz Derezinski,Grazyna Sypniewska

doi:10.3390/nu10101359

Lukasz Szternel, Magdalena Krintus + Show 3 more

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https://doi.org/10.3390/nu10101359

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Journal: Nutrients	Publication Date: Sep 22, 2018
Citations: 11	License type: CC BY 4.0

Affiliation: Nicolaus Copernicus University

Abstract

Background: The aim of this study was to assess the relationship between vitamin D status and the prevalence of dyslipidemia and impaired fasting glucose (IFG) in children. Methods and Summary: 284 children (150 boys and 134 girls) aged 9–11 were included in the study. Children with deficient 25(OH)D (25-hydroxycholecalciferol) levels ≤20 ng/mL (50 nmol/L) were characterized by a more frequent occurrence of impaired fasting glucose (IFG) (Odd ratios (OR) = 1.966, 95% confidence interval (CI): 1.055–3.663; p = 0.033) when compared to children with 25(OH)D >20 ng/mL. Serum 25(OH)D with concentration lower by 1 ng/mL (2.5 nmol/L) was linked to higher fasting glucose (by 0.25 mg/dL, 0.013 mmol/L; p = 0.017), higher total cholesterol (TC) by almost 1 mg/dL (0.96 mg/dL, 0.25 mmol/L; p = 0.006) and higher high-density lipoprotein cholesterol (HDL-C) (by 0.57 mg/dL, 0.015 mmol/L; p < 0.001). Conclusion: 25(OH)D deficiency may negatively affect fasting glucose and total cholesterol concentration in children aged 9–11. Vitamin D-deficient children are twice as likely to develop prediabetes as reflected by impaired fasting glucose when compared to those with a 25(OH)D level above 20 ng/mL (50 nmol/L).

Highlights

The prevalence of obesity and vitamin D deficiency among children makes this population demographic especially vulnerable to the development of these two pervasive epidemics [1]
Research suggests an unhealthy diet coupled with a sedentary lifestyle has become the main causal factor affecting the development of obesity, which in turn is frequently accompanied by dyslipidemia
In the whole group, high-density lipoprotein cholesterol (HDL-C) in the subgroup with hyperglycemia or total cholesterol (TC) and HDL-C in the subgroups with normo/hypercholesterolemia. Despite this weak correlation with lipid exponents, our study revealed a significant association between serum 25(OH)D and TC concentration

Summary

Introduction

The prevalence of obesity and vitamin D deficiency among children makes this population demographic especially vulnerable to the development of these two pervasive epidemics [1]. Epidemiological, and cross-sectional studies indicate an inverse correlation between the concentration of 25(OH)D (25-hydroxycholecalciferol) and the rate of conversion from a prediabetes state to fully symptomatic diabetes mellitus [3]. The aim of this study was to assess the relationship between vitamin D status and the prevalence of dyslipidemia and impaired fasting glucose (IFG) in children. Children with deficient 25(OH)D (25-hydroxycholecalciferol) levels ≤20 ng/mL (50 nmol/L) were characterized by a more frequent occurrence of impaired fasting glucose (IFG) (Odd ratios (OR) = 1.966, 95% confidence interval (CI): 1.055–3.663; p = 0.033) when compared to children with 25(OH)D >20 ng/mL. Conclusion: 25(OH)D deficiency may negatively affect fasting glucose and total cholesterol concentration in children aged 9–11. Vitamin D-deficient children are twice as likely to develop prediabetes as reflected by impaired fasting glucose when compared to those with a 25(OH)D level above 20 ng/mL (50 nmol/L)

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