Abstract
Over the past few decades, a growing body of epidemiological studies found the effects of temperature on cardiovascular disease, including the risk for acute myocardial infarction (AMI). Our study aimed to investigate whether there is an association between extremely temperature and acute myocardial infarction hospital admission in Beijng, China. We obtained 81029 AMI cases and daily temperature data from January 1, 2013 to December 31, 2016. We employed a time series design and modeled distributed lag nonlinear model (DLNM) to analyze effects of temperature on daily AMI cases. Compared with the 10th percentile temperature measured by daily mean temperature (Tmean), daily minimum temperature (Tmin) and daily minimum apparent temperature (ATmin), the cumulative relative risks (CRR) at 1st percentile of Tmean, Tmin and ATmin for AMI hospitalization were 1.15(95% CI: 1.02, 1.30), 1.24(95% CI: 1.11, 1.38) and 1.41(95% CI: 1.18, 1.68), respectively. Moderate low temperature (10th vs 25th) also had adverse impact on AMI events. The susceptive groups were males and people 65 years and older. No associations were found between high temperature and AMI risk. The main limitation of the study is temperature exposure was not individualized. These findings on cold-associated AMI hospitalization helps characterize the public health burden of cold and target interventions to reduce temperature induced AMI occurrence.
Highlights
From 1956 to 2005, the global average temperature rose by 0.13 ̊C per decade, and the number was 0.07 ̊C between 1906 to 1956[1]
This study examined the association between extreme temperature and acute myocardial infarction (AMI) hospital admission in China for the first time
Our study found that low temperature can increase the incidence of AMI
Summary
From 1956 to 2005, the global average temperature rose by 0.13 ̊C per decade, and the number was 0.07 ̊C between 1906 to 1956[1]. According to a World Health Organization survey, besides the increased temperature, the frequency and intensity of extreme weather have changed. The Intergovernmental Panel on Climate Change has demonstrated the effects of temperature variations (extreme heat episodes, sudden cold) on human health, including the effects on temperature- sensitive diseases. Extreme temperature and acute myocardial infarction hospital admissions [201509062], National Natural Science Foundation [41450006, 91643208], Beijing Medical Health Science and Technology Key-support Project [2014-1-4016], Chinese Academy of Medical Sciences (CAMS) Initiative for Innovative Medicine [2017-I2M-2-001, CAMS 2016ZX310181-4/5], National Key Research and Development Plan [2017YFC0211703], National 973 Project [2015CB553400], and Beijing Municipal Science and Technology Commission [Z131107002213176].
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