Association between extramural vascular invasion and iodine quantification using dual-energy computed tomography of rectal cancer: a preliminary study

Abstract

ObjectiveThis study aimed to investigate whether histopathological confirmed extramural vascular invasion (EMVI) is associated with quantitative parameters derived from dual-energy computed tomography (DECT) of rectal cancer. MethodsThis retrospective study included patients with rectal cancer who underwent rectal cancer surgery and DECT (including arterial-, venous-, and delay-phase scanning) between November 2019 and November 2020. The EMVI of rectal cancer was confirmed via postoperative pathological results. Iodine concentration (IC), IC normalized to the aorta (NIC), and CT attenuation values of the three phases were measured and compared between patients with and without EMVI. Receiver operating characteristic (ROC) curves were generated to determine the diagnostic performance of these DECT quantitative parameters. ResultsHerein, 36 patients (22 men and 14 women) with a mean age of 62 [range, 43–77] years) with (n = 13) and without (n = 23) EMVI were included. Patients with EMVI exhibited significantly higher IC in the venous and delay phases (venous-phase: 2.92 ± 0.6 vs 2.34 ± 0.48; delay-phase: 2.46 ± 0.47 vs 1.88 ± 0.35) and NIC in all the three phases (arterial-phase: 0.31 ± 0.12 vs 0.24 ± 0.06; venous-phase: 0.58 ± 0.11 vs 0.41 ± 0.07; delay-phase: 0.68 ± 0.10 vs 0.46 ± 0.08) than patients without EMVI. Among them, the highest area under the ROC curve (AUC) was obtained in the delay-phase NIC (AUC = 0.983). IC in the arterial-phase and CT attenuation in all the three phases did not significantly differ between patients with and without EMVI (p = 0.205–0.869). ConclusionIodine quantification using dual-energy CT, especially the NIC of the tumor, differs between the EMVI-positive and EMVI-negative groups and seems to help predict the EMVI of rectal cancer in this preliminary study; however, a larger sample size study is warranted in the future.