Abstract
Hox transcript antisense intergenic RNA (HOTAIR) is upregulated and associated with a poor prognosis in many cancer types. Besides, it is involved in the invasion and metastasis of non-small-cell lung cancer and nasopharyngeal carcinoma. The aim of this study was to investigate the association between the expression of HOTAIR and the grades of gliomas, and to explore its possible mechanism, as well as to evaluate the value of HOTAIR applied in predicting the grades of gliomas. A total of 123 patients undergoing glioma surgeries were enrolled. Patients with grade I and grade II-IV tumors were regarded as the control group (n = 36) and the case group (n = 87), respectively. The expression of HOTAIR, matrix metalloproteinase 7 (MMP-7), matrix metalloproteinase 9 (MMP-9), and vascular endothelial growth factor (VEGF) was detected with quantitative reverse transcription-polymerase chain reaction (qRT-PCR) in glioma tissues and then compared between grade I and grades II-IV. The correlation between the relative expression of HOTAIR and that of MMP-7, MMP-9 and VEGF was analyzed. Multivariate analysis was performed to identify independent risk factors. Receiver operating characteristic (ROC) curve was employed to evaluate the predictive value. The relative expression of HOTAIR, MMP-7, MMP-9, and VEGF was lower in glioma tissues of grade I than in the case of grades II-IV, and the relative expression of HOTAIR was positively correlated with the relative expression of MMP-7, MMP-9 and VEGF. Multivariate analysis showed that the relative expression of HOTAIR was independently associated with the grades of gliomas, but the relative expression of MMP-7, MMP-9 and VEGF was not. Besides, multivariate analysis showed that the expression level of HOTAIR >0.40 was an independent risk factor for grades II-IV after classifying the relative expression of HOTAIR, and ROC analysis showed that the expression level of HOTAIR >0.40 had a moderate value when applied in predicting grades II-IV. Hox transcript antisense intergenic RNA might promote the invasion of gliomas through upregulating the expression of MMP-7, MMP-9 and VEGF, and the expression level of HOTAIR >0.40 had a moderate value when applied in predicting grades II-IV.
Highlights
As the most common primary tumors in the central nervous system among adults,[1,2] gliomas are classified into 4 grades that reflect the degree of invasiveness/malignancy according to the current 2016 World Health Organization (WHO) Classification of Tumours of the Central Nervous System.[3]
The relative expression of Hox transcript antisense intergenic RNA (HOTAIR), matrix metalloproteinase 7 (MMP-7), matrix metalloproteinase 9 (MMP-9), and vascular endothelial growth factor (VEGF) was lower in glioma tissues of grade I than in the case of grades II–IV, and the relative expression of HOTAIR was positively correlated with the relative expression of MMP-7, MMP-9 and VEGF
Multivariate analysis showed that the expression level of HOTAIR >0.40 was an independent risk factor for grades II–IV after classifying the relative expression of HOTAIR, and Receiver operating characteristic (ROC) analysis showed that the expression level of HOTAIR >0.40 had a moderate value when applied in predicting grades II–IV
Summary
As the most common primary tumors in the central nervous system among adults,[1,2] gliomas are classified into 4 grades that reflect the degree of invasiveness/malignancy according to the current 2016 World Health Organization (WHO) Classification of Tumours of the Central Nervous System.[3]. Many studies have indicated that lncRNAs can be applied in predicting the prognosis in various cancer types.[5,6,7,8] Hox transcript antisense intergenic RNA is the first lncRNA discovered to have a trans-repressive role.[9,10] It is upregulated and associated with a poor prognosis in many cancer types.[11,12,13,14,15] Apart from that, it is involved in the invasion and metastasis of non-small-cell lung cancer and nasopharyngeal carcinoma through modulating the expression of matrix metalloproteinase 7 (MMP-7), matrix metalloproteinase 9 (MMP-9) and vascular endothelial growth factor (VEGF).[16,17] In this paper, the association between the relative expression of HOTAIR and the grades of gliomas was analyzed, and the possible mechanism was explored; the value of HOTAIR applied in predicting the grades of gliomas was evaluated. Hox transcript antisense intergenic RNA (HOTAIR) is upregulated and associated with a poor prognosis in many cancer types It is involved in the invasion and metastasis of non-small-cell lung cancer and nasopharyngeal carcinoma
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