Association between essential hypertension and bone mineral density: a systematic review and meta-analysis.

Ziliang Ye,Haili Lu,Peng Liu

doi:10.18632/oncotarget.20325

Ziliang Ye, Haili Lu + Show 1 more

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https://doi.org/10.18632/oncotarget.20325

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Abstract

BackgroundWe conducted this systematic review and meta-analysis to evaluate the association between essential hypertension (EH) and bone mineral density (BMD).Results17 articles were included in our meta-analysis, with a total of 39,491 patients. Of these, 13,375 were patients with EH and 26,116 were patients without EH. Meta-analysis results showed that EH can reduce the BMD of the lumbar spine (95% CI: −0.08∼0.01, P=0.006), femoral neck (95% CI: −0.09∼-0.02, p = 0.001), ward's triangle (95% CI: −0.45∼-0.25, p=0.000), femoral intertrochanteric (95% CI: −0.90∼-0.64, p = 0.000), calcaneus (95% CI: −0.31∼-0.18, p = 0.000) and distal forearm (95% CI: −0.09∼-0.03, p = 0.000), but EH cannot reduce the BMD of the femur rotor (95% CI: −0.07∼0.24, p = 0.273). Subgroup analysis showed that EH can reduce the BMD of the lumbar spine (95% CI: −0.11∼-0.03, p = 0.000) and femoral neck (95% CI: −0.11∼-0.07, p = 0.000) in Asian populations. In non-Asian populations, EH can reduce the BMD of the femoral neck (95% CI: 0.04∼0.19, p = 0.002), but cannot reduce the BMD of the lumbar spine (95% CI: −0.04∼0.11, p = 0.346).Materials and MethodsWe conducted a systematic review of the published literature on the association of EH and BMD by searching the Cochrane Library, PubMed, EMBASE, CBM, CNKI and VIP databases inception to October 2016. Stata 11.0 software was used for data analysis.ConclusionsOur meta-analysis suggests that EH can reduce the BMD of the human body, and for different parts of the bone, the degree of reduction is different. In addition, for different regions and populations, the reduction level of BMD is inconsistent.

Highlights

With society’s trending toward aging and unhealthy lifestyle changes, the prevalence rate of essential hypertension (EH) and osteoporosis (OP) increases every year, and these have become two of the most common diseases in the world [1,2,3]
Meta-analysis results showed that EH can reduce the bone mineral density (BMD) of the lumbar spine, femoral neck, ward's triangle, femoral intertrochanteric, calcaneus and distal forearm, but EH cannot reduce the BMD of the femur rotor
Subgroup analysis showed that EH can reduce the BMD of the lumbar spine and femoral neck in Asian populations

Summary

Introduction

With society’s trending toward aging and unhealthy lifestyle changes (such as high heat, high fat food intake increase and reduction in physical activity), the prevalence rate of essential hypertension (EH) and osteoporosis (OP) increases every year, and these have become two of the most common diseases in the world [1,2,3]. Treating and nursing patients with osteoporosis and osteoporosis fracture requires an investment in manpower and material resources but is expensive. This high cost is not conducive to a society’s goal of a harmonious and stable development; identifying risk factors to prevent osteoporosis has become one of the hot issues. We conducted this systematic review and meta-analysis to evaluate the association between essential hypertension (EH) and bone mineral density (BMD)

Methods

Results

Conclusion